Epigenetic regulation of systemic iron homeostasis (Masters option available)

Epigenetic regulation of systemic iron homeostasis (Masters option available)

Project details

Our group works on basic, translational, clinical and public health aspects of anaemia control. Systemic iron homeostasis is regulated by the liver-derived hormone, hepcidin. Mis-regulation of this hormone is central to most iron disorders. We recently provided the first evidence of epigenetic regulation of this hormone (Pasricha et al Nat Commun 2016 Sep 1;8(1):403.)

This project will use a combination of cutting edge epigenetic (eg chromosome conformation capture, ATAC-Seq, ChIP), genome editing (i.e. CRISPR-Cas9), cell culture (eg siRNA) and molecular (eg qPCR) techniques to further characterise the regulation of hepcidin. Students will learn a series of high throughput sequencing methods, as well as become familiar with aspects of iron biology. 

About our research group

We combine basic experimental science with research in global health. In the laboratory, we study how the master controller of systemic iron homoestasis, hepcidin, is regulated. We are using novel epigenetic approaches to characterise new pathways which may regulate hepcidin gene expression. In the field, we are undertaking large randomized controlled trials of iron interventions in rural Bangladesh (infants) and Malawi (pregnant women). These trials will provide much needed evidence to inform global health anaemia control policies. Finally, we assist and advise international and national organisations with research and policy development.

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