Eosinophil maturation

Eosinophil maturation

Project details

The use of transcription factor knockouts to delineate the step-wise maturation of adaptive immune cells has facilitated a deep understanding of how these adaptive cells develop; however this sort of information is lacking for eosinophils. Therefore, we would like to probe the development of eosinophils and whether this happens in a step-wise fashion dictated by transcription factors. We have unique access to a range of genetic models that allow us to precisely control the transcription factors present during eosinophil development. These models will allow us to address if there is a stepwise transition from a GMP through intermediate stages to an eosinophil progenitor and then a mature eosinophil.

About our research group

The Hilton laboratory studies the development and function of blood cells, with a current focus on granulocytes. We aim to identify genes and molecular pathways that are important in regulating normal blood cell production and understand the changes that lead to blood cell disorders such as autoimmunity, inflammatory diseases, and leukemia. We work with clinicians and industry partners to find better ways of treating these illnesses.

We take a multidisciplinary approach combining cell biology, physiology, biochemistry and molecular biology, genomics, bioinformatics and computational science to understand the blood cell system and its individual lineages. We also develop software that assists biologist in visualising and interacting with large data sets. We have a team of talented motivated post-docs ready to teach you the latest techniques.

 

 

Researchers:

Professor Doug Hilton

Professor Doug Hilton in the office
Professor
Doug
Hilton
Institute Director, Division Head
Dr Kirsten Fairfax profile photo
Dr
Kirsten
Fairfax
Molecular Medicine division
Dr Carolyn deGraaf profile photo
Dr
Carolyn
deGraaf
Molecular Medicine division

Project Type: