Eosinophil death

Eosinophil death

Project details

This project will investigate the role of extrinsic apoptosis in regulating eosinophil lifespan, which is poorly understood. Extrinsic apoptosis occurs when extracellular ligands (such as Fas ligand, TNF, TRAIL) bind to cell surface death receptors (such as Fas receptor), triggering cell death. We will use genetic models to specifically remove components of the extrinsic apoptosis pathway and examine the impact on eosinophil number and survival. This will enable the formal demonstration of the relative importance of extrinsic apoptosis in the regulation of eosinophil lifespan. 

The successful applicant will learn great molecular, cellular and quantitative biological methods.

About our research group

The Hilton laboratory studies the development and function of blood cells, with a current focus on granulocytes. We aim to identify genes and molecular pathways that are important in regulating normal blood cell production and understand the changes that lead to blood cell disorders such as autoimmunity, inflammatory diseases, and leukemia. We work with clinicians and industry partners to find better ways of treating these illnesses.

We take a multidisciplinary approach combining cell biology, physiology, biochemistry and molecular biology, genomics, bioinformatics and computational science to understand the blood cell system and its individual lineages. We also develop software that assists biologist in visualising and interacting with large data sets. We have a team of talented motivated post-docs ready to teach you the latest techniques.

 

 

Researchers:

Professor Doug Hilton

Professor Doug Hilton in the office
Professor
Doug
Hilton
Institute Director, Division Head
Dr Kirsten Fairfax profile photo
Dr
Kirsten
Fairfax
Molecular Medicine division
Dr Carolyn deGraaf profile photo
Dr
Carolyn
deGraaf
Molecular Medicine division

Project Type: