Eosinophil activation

Eosinophil activation

Project details

We will utilise the Institute’s drug-discovery pipeline to investigate candidate molecules that impact on the activation of eosinophils. 

It is well established that eosinophils accumulate proximal to parasitic worms (helminths) when these parasites invade tissue. This eosinophil accumulation is due to enhanced production of eosinophils in the bone marrow as well as enhanced survival in the presence of helminths. 

A class of pheromones (ascarosides) conserved across many species of helminths has recently been described and purified. We will use suspension cultures to determine if ascarosides can directly affect the generation of eosinophil colonies from stem cell precursors.

The successful applicant will learn great molecular, cellular and quantitative biological methods.

 

About our research group

The Hilton laboratory studies the development and function of blood cells, with a current focus on granulocytes. We aim to identify genes and molecular pathways that are important in regulating normal blood cell production and understand the changes that lead to blood cell disorders such as autoimmunity, inflammatory diseases, and leukemia. We work with clinicians and industry partners to find better ways of treating these illnesses.

We take a multidisciplinary approach combining cell biology, physiology, biochemistry and molecular biology, genomics, bioinformatics and computational science to understand the blood cell system and its individual lineages. We also develop software that assists biologist in visualising and interacting with large data sets. We have a team of talented motivated post-docs ready to teach you the latest techniques.

Further reading

  • Rosenberg, HF, Dyer, KD & Foster, PS. Nature reviews. Immunology 13, 9, (2013).
  • Johnston, LK, et al. Journal of immunology 197, 3445, (2016).
  • Choe, A, et al. Current biology : CB 22, 772, (2012).

 

 

Researchers:

Professor Doug Hilton

Professor Doug Hilton in the office
Professor
Doug
Hilton
Institute Director, Division Head
Dr Kirsten Fairfax profile photo
Dr
Kirsten
Fairfax
Molecular Medicine division
Dr Carolyn deGraaf profile photo
Dr
Carolyn
deGraaf
Molecular Medicine division

Project Type: