Elucidation of long range methylation structure using nanopore sequencing (Masters option available)

Elucidation of long range methylation structure using nanopore sequencing (Masters option available)

Project details

DNA methylation is a key epigenetic factor in regulation of gene expression. There is already clear evidence from short read analysis of spatial dependence in the pattern of methylation.

Nanopore sequencing is now allowing considerable advances in identifying long range structure in the distribution of methylation. This project will exploit nanopore sequencing to analyse long range methylation structure at the single fragment level, and seek to derive quantitative descriptions of such structure.

This project will provide exposure to the latest in sequencing technology, to the world of epigenetics and gene regulation, and to the application of various statistical, signal processing and computational analyses for understanding genomic sequence data.

About our research group

The Speed laboratory addresses a broad set of challenges in transforming raw quantitative data from biological and biomedical studies into valid and understandable form. 

Our research includes development of improved statistical techniques for combining data across collection conditions, finding better ways to extract and interpret single cell expression from various technologies, and extending machine learning techniques to interpret nanopore sequencer signals.  

 

 

Researchers:

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Dr
Chris
Woodruff
Bioinformatics division

Project Type: