Defining the role of necroptosis in platelet production and function

Defining the role of necroptosis in platelet production and function

Project details

Necroptosis is a newly discovered pathway of programmed necrosis, with links to inflammation, and is induced by death receptors, interferons, toll-like receptors and intracellular RNA and DNA sensors. This project will define the role of necroptosis in megakaryocytes and platelets. 

About our research group

Our laboratory is interested in understanding the molecular pathways that regulate platelet production and function in health and disease. We previously characterised the intrinsic and extrinsic apoptotic machinery in megakaryocytes (Josefsson, Nat Commun 2014 5(3455), Josefsson, J Exp Med 2011 208(10):2017) where we identified the selective pro-survival proteins (Bcl-xL and Mcl-1) as essential for keeping megakaryocytes alive and discovered that the apoptotic death machinery can be triggered by chemotherapy treatment and by viral infection. 

Another interest in our laboratory lies in better understanding the role of platelets in cancer progression (Hyslop, Sci Rep. 2017 7(1):14953). 

Researchers:

Dr Emma Josefsson

Dr Emma Josefsson
Dr
Emma
Josefsson
Laboratory Head

Project Type: