Deciphering biophysical changes in red blood cell membrane during malaria parasite infection

Deciphering biophysical changes in red blood cell membrane during malaria parasite infection

Project details

Malaria is one of the deadliest diseases in the world, causing almost half a million deaths each year, among which a significant proportion are children. Developing an effective vaccine or drug treatment against this devastating disease depends on having a more detailed understanding about the mechanisms governing parasite interactions at the red blood cell membrane and formation of the parasitophorous vacuole.

This project will use cutting edge microscopy techniques in combination with novel computational approaches to decipher how the malaria parasite induces biophysical changes in the red blood cell membrane and the mechanism by which the host cell membrane reseals after invasion. These studies could lead to the identification of novel drug targets or vaccine candidates, which are sort in the fight against this devastating disease.

About our research group

The Rogers lab uses cutting-edge imaging technologies, such as Lattice light sheet microscopy, which enable biological processes to be visualised with an unprecedented level of detail. Students will work within a multidisciplinary team where there is expertise in biology, physics, image analysis and engineering. This environment will provide students with the unique opportunity to gain a broad set of interdisciplinary skills, with a major focus on making biological discoveries through the use of novel technologies and computational approaches. This work is undertaken in very close collaboration with Professor Alan Cowman and his team who are experts in the field of malaria parasite biology.

Researchers:

Dr Kelly Rogers

Dr Kelly Rogers at a microscope
Dr
Kelly
Rogers
Division Head; Head, Centre for Dynamic Imaging

Project Type: