Controlling apoptotic cell death in cancer

Controlling apoptotic cell death in cancer

Project details

Apoptotic cell death is critical development but is also emerging as an important therapeutic target to treat diseases ranging from cancer to neurodegenerative conditions. 

My lab utilises novel cell biology and biochemical approaches to interrogate how apoptosis is controlled so that we might better target the process to treat disease. We have identified several novel putative regulators of apoptosis. 

This project will characterise the role of these proteins in regulating cell death and also investigate their potential role in cancer development. The project will involve diverse approaches including cell culture, mutagenesis, protein chemistry, mass spectrometry and high-resolution microscopy.


About our research group

Our lab currently comprises two PhD students, a research assistant, a post-doctoral researcher and an undergraduate student. Each member of our lab has their own research focus within the broader context of understanding the fundamental processes of apoptosis and mitochondrial quality control (mitophagy) and how these processes influence disease including cancer.

We collaborate widely within the Institute and also with external labs. Research positions are available for both PhD and Honours students with a passion for biological research and an interest in cancer biology.

Selected papers:

Li et al, PNAS 2017, 114(29):7629-7634
Dewson EMBO J 2016 35(4):371-3
Ma et al Cell Death & Differ 2014 21(12):1925-35 
Westphal et al Cell Death & Differ 2014 21(2):196-205
Dewson et al Mol Cell 2008 30:369-380



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