Cell death, homeostasis and senescence in the immune system

Cell death, homeostasis and senescence in the immune system

Project details

The ability of the adaptive immune system to mount an antibody response against virtually any pathogen relies on a diverse B cell repertoire, and on the continuous generation of newly generated B cells in the bone marrow. 

It is well established that the number of B cells produced in the bone marrow diminishes with age. This is thought to limit the effectiveness with which the elderly mount protective antibody responses. The mechanisms underpinning this phenomenon are still obscure. 

We have recently generated a novel model of immune senescence. Using gene expression profiling, cell biology and genome editing techniques, this project will explore the relationship between cell death, normal homeostasis and senescence, and how perturbations in these processes contribute to cancer.


About our research group

The Kile lab has a longstanding interest in haematopoiesis and cell death. Using primarily molecular approaches, we seek to understand the role of pathways such as apoptosis, pyroptosis and necroptosis in haematopoietic biology. This includes elucidating pathways at steady state, and in disease settings such as leukemia and inflammatory disease. Our work extends to the development of new chemical probes to study cell death in the haematopoietic system and other tissues.




Stephane Chappaz profile photo
ACRF Chemical Biology division

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