Autoimmunity to neutrophils in COVID-19 severity and co-morbidities

Autoimmunity to neutrophils in COVID-19 severity and co-morbidities

Project details

Neutrophils are the most common type of white blood cells. Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies that can target these cells and in doing so can induce inflammatory responses that are detrimental to the host. This can worsen the severity of symptoms experienced during an infection. This may be an important factor contributing to severity of COVID-19 when a person becomes infected with SARS-CoV-2.

This project will investigate the presence of ANCA and other inflammatory molecules in individuals that have been infected with SARS-CoV-2 and determine whether they are increased in individuals with severe disease associated with other co-morbidities and co-infections. This will involve basic assay development, usage of common immunological in vitro assays and data analysis of large datasets.

About our research group

The Mueller Lab specializes in clinically related studies of large cohorts with focus on antibody profiling and innate immune responses. The laboratory consists of 4 postdoctoral researchers, 1 PhD student, 1 Masters student and 1 research assistant with expertise in immunology, serology and epidemiology.

The Coussens Lab specializes in the role of innate immunity in the pathogenesis and tissue destruction associated with chronic infections, tuberculosis and HIV-1. We combine analysis of clinical samples to identify novel pathways of pathogenesis in humans, with in vitro models of TB and HIV infection to identify the molecular mechanism underlying disease risk. 

Email supervisors

 

 
 

Researchers:

Dr Emily Eriksson
Dr
Emily
Eriksson
Population Health and Immunity

Dr Anna Coussens

Dr Anna Coussens in a laboratory
Dr
Anna
Coussens
Laboratory Head

Professor Ivo Mueller

Professor Ivo Mueller
Professor
Ivo
Mueller
Joint Division Head

Project Type: