Apoptotic caspases, cell death, infection, inflammation and cancer

Apoptotic caspases, cell death, infection, inflammation and cancer

Project details

Caspases are critical mediators of programmed cell death. We recently demonstrated that they are not only involved in killing cells, but in preventing dying cells from signalling to the immune system (White, Cell 2014 159(7):1549). 

This has raised fundamental questions about how caspases facilitate embryonic development, and how they function in disease settings such as viral infection and cancer

This project will utilise genetics and cell biology to unravel these processes and establish whether drugs that inhibit caspases might have clinical potential.

 

About our research group

The Kile lab has a longstanding interest in haematopoiesis and cell death. Using primarily molecular approaches, we seek to understand the role of pathways such as apoptosis, pyroptosis and necroptosis in haematopoietic biology. This includes elucidating pathways at steady state, and in disease settings such as leukaemia and inflammatory disease. Our work extends to the development of new chemical probes to study cell death in the haematopoietic system and other tissues.

 

 

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