3D and 4D imaging of thymic T cell differentiation

3D and 4D imaging of thymic T cell differentiation

Project details

The process of turning bone marrow progenitor cells into the many different types of T cells required for immunity is orchestrated by epithelial cells in the thymus. The mesh-like thymic epithelium facilitates the generation of T cells are functional, yet tolerant of self.

In this project, we will apply new imaging approaches for 3D resolution of these cells to determine how they control T cell differentiation. In addition, in vivo imaging approaches will be used to address these processes in real-time. The data generated will shed new light on the complex process of T cell differentiation and how it might be boosted in patients receiving harsh cancer treatment regimes that compromise thymic and immune function. 

 

About our research group

This project will draw upon years of experience in thymus biology within the Gray Laboratory. It will be led by Senior Postdoctoral Fellow, Dr Julie Sheridan, and draw upon key collaborations with Associate Professor Edwin Hawkins and the Centre for Dynamic Imaging to drive innovative approaches to solving fundamental problems in the field. 

 

Graph of research data
Although poorly understood, interactions with thymic epithelial cells governs the fate of developing
T cells. In this image, the tightly packed nuclei of all thymus cells can be seen (grey) and we can
identify epithelial cells (magenta) interacting with cells of the regulatory T cell lineage (cyan). 

 

Researchers:

Julie Sheridan
Dr
Julie
Sheridan
Molecular Genetics of Cancer division

Project Type: