Following my PhD studies in developmental haematopoiesis with Professor Alexander Medvinsky at the University of Edinburgh, in 2008 I moved to The Walter and Eliza Hall Institute (WEHI) to undertake a postdoc in the laboratory of Professor Doug Hilton.
In 2011, I started my own laboratory at WEHI with a consistently innovative research program focused on the biology of blood production and function. As an independent laboratory head, I have developed a track record of securing competitive research funding, providing an exceptional learning experience for my research students, career progression for my team members, and publishing high quality research in top scientific journals.
In brief, my research team uses cutting edge imaging, clonal tracking (cellular barcoding), genomics technologies, and functional assays (in vivo and in vitro) to tackle long-standing questions about the biology of blood production. My current research strategy incorporates commercial and translational elements to complement my discovery research program. We have a growing emphasis on the application of our new knowledge to understand and target diseases including thrombocytopenia and neonatal stroke.
United Kingdom, University of Edinburgh, PhD, 2006
2023 – 2025, NH&MRC project grant. GNT2019912 “Understanding how platelets prevent fetal and neonatal stroke”. Role, Chief-Investigator A.
2022 – 2027, NH&MRC project grant. GNT2011770 “Upending the platelet paradigm: Targeting actin-driven membrane budding to modulate platelet production in health and disease”. Role, Chief-Investigator A.
2022 – 2027, DHB foundation. “Defining the rules of platelet production: understanding biology to treat disease”. Role, Chief-Investigator.
2022 – 2024, Norman Beischer Medical Research Foundation Innovation award. “Identifying how platelets prevent stroke in neonates”. Role, Chief-Investigator.
2020 – 2021, Lorenzo and Pamela Galli Charitable Trust Centenary Fellowship. Role, Chief-Investigator A.
2021, Speedy Innovation award. Role, Chief-Investigator.
2020, Innovation award. Role, Chief-Investigator.
2019 – 2021, Cerebral Palsy Alliance Research Foundation. PG12418: “Exploring a causal relationship between Cerebral Palsy and platelets: defining the aetiology and therapeutic window of neonatal stroke”. Role, Chief-Investigator.
2017 – 2019, NH&MRC project grant. GNT1128993: “Investigating the formation and utility of the prenatal platelet forming system”. Role, Chief-Investigator.
2017 – 2019, NH&MRC project grant. GNT1129012: “Understanding the ancestry of de novo blood formation in the early embryo”. Role, Chief-Investigator.
2012 – 2014, ARC DECRA fellowship. Role, Chief-Investigator.
2011 – 2018, ARC Stem Cells Australia program – blood theme. Role, co-chief-investigator.
Biben, C., Weber T.S., Potts, K.S., Choi. J., Miles, D.C., Carmagnac, A., Sargeant, T., de Graaf, C.A., Fennell, K.A., Farley, A., Stonehouse, O., Dawson, M.A., Hilton, D.J., Naik, S.H.*, and Taoudi, S*. “A trio of bipotent precursors seeds the haemato-endothelial lineages of the yolk sac” (2023) Nat Comms, https://doi.org/10.1038/s41467-022-35744-x. PMID: 36596806
Potts, K. S., A. Farley, C. A. Dawson, J. Rimes, C. Biben, C. de Graaf, M. A. Potts, O. J. Stonehouse, A. Carmagnac, P. Gangatirkar, E. C. Josefsson, C. Anttila, D. Amann-Zalcenstein, S. Naik, W. S. Alexander, D. J. Hilton, E. D. Hawkins and Taoudi, S. (2020). “Membrane budding is a major mechanism of in vivo platelet biogenesis.” J Exp Med 217(9). PMID: 32706855
Potts, K. S., T. J. Sargeant, C. A. Dawson, E. C. Josefsson, D. J. Hilton, W. S. Alexander and Taoudi, S. (2015). “Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.” Blood 126(6): 807-816. PMID: 25995324
Potts, K. S., T. J. Sargeant, J. F. Markham, W. Shi, C. Biben, E. C. Josefsson, L. W. Whitehead, K. L. Rogers, A. Liakhovitskaia, G. K. Smyth, B. T. Kile, A. Medvinsky, W. S. Alexander, D. J. Hilton and Taoudi, S. (2014). “A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo.” Blood 124(17): 2725-2729. PMID: 25079356
Weber T.S., Biben, C., Miles, D.C., Zhang, S., Tam, P., Taoudi, S*., and Naik, S.H.*. “¬-LoxCode in vivo clonal barcoding resolves mammalian epiblast contribution to fetal organs”. bioRxiv (2023): doi: https://doi.org/10.1101/2023.01.02.522501.
Terreaux, A., Farley, A., Biben, C., Stonehouse, O., and Taoudi, S. “Analysis of organelle content supports a membrane budding model of platelet biogenesis”. bioRxiv (2022): doi: https://doi.org/10.1101/2022.05.21.492939.
Farley, A., S. Lloyd, M. Dayton, C. Biben, O. Stonehouse and Taoudi, S. (2022). “Cerebral vasculature exhibits dose-dependent sensitivity to thrombocytopenia that is limited to fetal/neonatal life” Blood 139(15):2355-2360. PMID: 35148538
Farley, A., S. Lloyd, M. Dayton, C. Biben, O. Stonehouse and Taoudi, S. (2021). “Severe thrombocytopenia is sufficient for fetal and neonatal intra-cerebral hemorrhage to occur.” Blood 138(10):885-897. PMID: 34189583
Kazenwadel, J., Venugopal, P., Piltz, S.G., Brown, C., Taoudi, S., Thomas, P.Q., Scott, H.S., and Harvey, N.L. “Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer.” (2023) Nature 614: 343-348. PMID: 36697821
Chandrakanthan, V., Rorimpandey, P., Zanini, Z., Kang, Y.C., Knezevic, K., Huang, Y., Chacon, D., Qiao, Q., Oliver, R.A., Unnikrishnan, A., Carter, D.R., Lee, B., Brownlee, C., Power, C., Mendez-Ferrer, S., Enikolopov, G., Walsh,W., Gottgens, B., Taoudi, S., Beck, D., and Pimanda, J.E. “Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta.” Nat Cell Biol 24(8):1211-1225. PMID: 35902769
Monagle, P., Ng, AP., Linden, M, Ignjatovic, V., Farley, A., Taoudi, S., Pascricha, S.R., and Torresi, J (2021). “Vaccine-induced immune thrombosis and thrombocytopenia syndrome following adenovirus-vectored severe acute respiratory syndrome coronavirus 2 vaccination: a novel hypothesis. Immunol Cell Biol 99(10):1006-1010. PMID:
Lin, D. S., L. Tian, S. Tomei, D. Amann-Zalcenstein, T. M. Baldwin, T. S. Weber, J. Schreuder, O. J. Stonehouse, J. Rautela, N. D. Huntington, Taoudi, S., M. E. Ritchie, P. D. Hodgkin, A. P. Ng, S. L. Nutt and S. H. Naik (2021). “Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development.” Nat Cell Biol 23(3): 219-231. PMID: 33649477
Amann-Zalcenstein, D., L. Tian, J. Schreuder, S. Tomei, D. S. Lin, K. A. Fairfax, J. E. Bolden, M. D. McKenzie, A. Jarratt, A. Hilton, J. T. Jackson, L. Di Rago, M. P. McCormack, C. A. de Graaf, O. Stonehouse, Taoudi, S., W. S. Alexander, S. L. Nutt, M. E. Ritchie, A. P. Ng and S. H. Naik (2020). “A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics.” Nat Immunol 21(12): 1574-1584. PMID: 33077975
Easterbrook, J., S. Rybtsov, S. Gordon-Keylock, Ivanovs, A., Taoudi, S., Anderson, R. A., and Medvinsky, A. (2019). “Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.” Stem Cell Reports 12(5): 1056-1068. PMID: 30956115
Taoudi, S. (2018). “NOTCHing down a win for megakaryocytes.” Blood 131(2): 158-159. PMID: 29326349
Souilhol, C., C. Gonneau, J. G. Lendinez, A. Batsivari, S. Rybtsov, H. Wilson, L. Morgado-Palacin, D. Hills, Taoudi, S., J. Antonchuk, S. Zhao and A. Medvinsky (2016). “Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.” Nat Comms 7: 10784. PMID: 26952187
Taoudi, S. (2016). “High-JAKing the blood: resistance is fetal.” Blood 127(19): 2267-2268. PMID: 27206663
Rybtsov, S., M. Sobiesiak, Taoudi, S., C. Souilhol, J. Senserrich, A. Liakhovitskaia, A. Ivanovs, J. Frampton, S. Zhao and A. Medvinsky (2011). “Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.” J Exp Med 208(6): 1305-1315. PMID: 21624936
Medvinsky, A., S. Rybtsov and Taoudi, S. (2011). “Embryonic origin of the adult hematopoietic system: advances and questions.” Development 138(6): 1017-1031. IF = 7. Citations = 456. PMID: 21343360
Taoudi, S., T. Bee, A. Hilton, K. Knezevic, J. Scott, T. A. Willson, C. Collin, T. Thomas, A. K. Voss, B. T. Kile, W. S. Alexander, J. E. Pimanda and D. J. Hilton (2011). “ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification.” Genes Dev 25(3): 251-262. PMID: 21245161
Taylor, E., Taoudi, S., and Medvinsky, A. (2010). “Hematopoietic stem cell activity in the aorta-gonad-mesonephros region enhances after mid-day 11 of mouse development.” Int J Dev Biol 54(6-7): 1055-1060. PMID: 20711982
Sheridan, J. M., Taoudi, S., Medvinsky, A., and C. C. Blackburn (2009). “A novel method for the generation of reaggregated organotypic cultures that permits juxtaposition of defined cell populations.” Genesis 47(5): 346-351. PMID: 19370754
Medvinsky, A., Taoudi, S., S. Mendes and E. Dzierzak (2008). “Analysis and manipulation of hematopoietic progenitor and stem cells from murine embryonic tissues.” Curr Protoc Stem Cell Biol Chapter 2: Unit 2A 6. PMID: 18770635
Taoudi, S., C. Gonneau, K. Moore, J. M. Sheridan, C. C. Blackburn, E. Taylor and A. Medvinsky (2008). “Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+CD45+ pre-definitive HSCs.” Cell Stem Cell 3(1): 99-108. PMID: 18593562
Taoudi, S. and A. Medvinsky (2007). “Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta.” Proc Natl Acad Sci U S A 104(22): 9399-9403. PMID: 17517650
Taoudi, S., A. M. Morrison, H. Inoue, R. Gribi, J. Ure and A. Medvinsky (2005). “Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver.” Development 132(18): 4179-4191. PMID: 16107475
Our objective with the platelet biogenesis program is to build on our innovations to develop novel therapeutics and methods for laboratory-based platelet production. This will be achieved by:
Team members: Dr Alison Farley, Mr Antoine Terreaux, Dr Tishya Indran
Building on our discovery that the first phase of blood formation in the yolk sac occurs via three bipotent precursors (haemangioblast, mesenchymoangioblast, and haematomesoblast), we are using single-cell technologies to investigate haematopoietic stem cell formation, mature haematopoietic lineage formation and function, and on the development of the fetal vasculature.
Team members: Dr Christine Biben
We aim to generate a mechanistic understanding about how bleeding in the fetal and neonatal brain is caused in the absence of platelets. We will identify pathways that could be targeted to prevent or ameliorate the severity of stroke where there is a risk.
To this end, our studies will:
Team members: Dr Alison Farley