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- Analysis and reporting of whole genome sequencing data from malaria parasites
- Analysis of long read data from the minION, with application to malaria
- Analysis of short tandem repeat markers from whole genome sequencing
- Antibody longevity following Plasmodium vivax infections
- Antigenic diversity of malaria parasites: towards more effective malaria vaccines
- Biogenesis of eosinophil granules
- Biological sequence analysis and genomic variant discovery
- Biology of the unique intra-mitochondrial bacterium Midichloria mitochondrii
- Characterising regulatory T cells in coeliac disease
- Chemical probing to identify effectors of necroptotic cell death
- Computational systems biology of Wnt/cell adhesion signalling in colon cancer
- Controlling apoptotic cell death in cancer
- Deciphering mechanisms of thrombocytopenia (low platelet count) in blood cancers
- Defining molecular signatures of drug resistance and sensitivity
- Designing immunotherapy for brain cancer
- Developing non-invasive methods to monitor kidney transplant rejection
- Discovery and analysis of autoimmune regulators
- Discovery of novel drug combinations for the treatment of bowel cancer
- Drug targets and compounds that block growth of malaria parasites
- Dying to survive: mechanistic insights into human bowel cancer development
- Dynamic discovery of innate immunity through imaging and genomics
- Dysregulation of TNF expression in inflammatory diseases
- Effects of nutrition on immunity and infection in Asia and Africa
- Elucidation of long range methylation structure using nanopore sequencing
- Eosinophil activation
- Eosinophil death
- Eosinophil heterogeneity
- Eosinophil maturation
- Epigenetic regulation of systemic iron homeostasis
- Epigenetic regulation of the immune system
- Explosive cell death and human disease
- Export of malaria virulence proteins during liver infection
- Function of proteins involved in invasion of erythrocytes by malaria parasites
- Functional genomics to improve therapeutic options for rare cancers
- Giardia duodenalis phosphoproteome and protein kinase network
- Harnessing the immune system to target small cell lung cancer
- Home renovations: understanding how Toxoplasma redecorates its host cell
- How do malaria parasites traverse human cells and invade hepatocytes?
- How does the malaria parasite prevent the host liver cell from dying?
- Human monoclonal antibodies against malaria infection
- IL5 signalling in asthma
- Identification of genes critical for the control of chronic infections
- Identification of malaria parasite entry receptors
- Identifying new cell death and inflammatory pathways
- Identifying proteome signatures of high grade glioma for precision medicine
- Insight into the cytotoxic T cell immune synapse
- Investigating apoptosis control in tumour blood vessels
- Investigating brain abnormalities with single cell ‘omics
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating the mechanics of platelet formation
- Investigating the molecular regulation of neovascular eye disease
- Let me in! How Toxoplasma invades human cells
- Long-read sequencing for transcriptome and epigenome analysis
- Machine learning analysis of mutagenesis datasets
- Macro-evolution in cancer
- Mapping human gene mutations affecting anti-malarial drug efficacy
- Mechanism and modulation of K+ channels and membrane transporters
- Mechanisms of disease relapse in acute lymphoblastic leukaemia
- Microbiome analysis using long read nanopore sequencing
- Molecular mechanism underpinning dendritic cell ontogeny and functions
- Molecular mechanisms of innate immune signalling
- Next-generation mucolytics to treat lung diseases
- No sex please, we’re inhibited: searching for drugs to prevent malaria transmission
- Novel biomarkers and mechanisms of antimalarial drug resistance
- Novel real-time, quantitative imaging approaches for studying malaria
- Novel regulators of JAK-STAT signalling in development and disease
- Novel tool for malaria surveillance and intervention
- Optimising serological markers of recent exposure to Plasmodium vivax
- Quantitation of human T cell responses in primary immunodeficiency
- Reconciling intracellular imaging and metastatic behaviour in cancer cells
- Reconstructing the immune response: from molecules to cells to systems
- Role of protein glycosylation in malaria virulence
- Statistical bioinformatic analyses of RNA-seq and ChIP-seq data
- Strategies mammalian cells use to survive without growth factors
- Structural and biochemical studies on Notch signal transduction
- Structural and functional analysis of malaria invasion
- Structural biology and binding studies of BCL-2 family proteins
- Structural studies of invasion processes during malaria infection
- Structural studies of the Plasmodium and Toxoplasma tight-junction complex
- Target identification of potent antimalarial agents
- The role of glycosylation in malaria vaccine design
- Towards a molecular description of plasma cell diversity
- Tracking the spread of malaria in the Asia Pacific region
- Transmembrane control of type I cytokine receptor activation
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding resistance to apoptotic cell death
- Understanding the common through study of the rare
- Understanding the development of humoral immunity to malaria
- Unravelling cellular circuitry with single cell RNA-seq and CRISPR
- Unravelling the molecular architecture of killer T cells in disease
- Why is interleukin-11 elevated in acute myeloid leukaemia?
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- WEHI.TV
Proteomics

Proteins are fundamental to the structure and function of cells. Proteomics studies the diverse set of proteins within cells, their proteome. Our researchers are using proteomics to better understand how proteins function in health and disease. This is providing new avenues for diagnosis and treatment of disease.
Our proteomics research
Our researchers are using proteomics to understand how proteins function within cells in health and disease. Important aspects include:
- Characterising the proteins involved in health and disease to understand their function.
- Developing proteomic strategies to improve diagnosis of diseases, including malaria and rheumatoid arthritis.
Our proteomics research is integrated with other research fields including:
What is proteomics?
Proteins are intricate molecules that are crucial for processes that make cells function. Proteomics studies the proteins produced by cells, called the proteome.
The proteomes of cells can vary:
- Within the same cell over time, such as in response to a stimulus.
- Between different types of cells, such as a neuron versus a red blood cell.
Differences between how cells function occur because of the variations in their proteomes. These differences can be seen in:
- The different types of proteins present.
- The amounts of each protein.
- Small chemical changes to proteins, such as phosphorylation (addition of a phosphate group).
- How proteins change their interactions with each other (signalling)
These differences can be linked to changes that occur in cells to cause disease, or in response to a disease.
Studying proteomes can provide insights into cell behaviour that may not be reached by looking at a few individual proteins. Proteomics also allows researchers to discover previously unknown changes in individual proteins that may not have been considered in studies of single proteins.
Proteomics also complements genomics research, as changes in a cell’s genetic material do not always reflect changes within the proteome.
Proteomics of disease
Cells contain thousands of different proteins that can be present in different amounts, and many proteins can be subtly modified. Our proteomics researchers rely on high-throughput techniques to rapidly assess and compare the proteomes of different samples.
Key aspects of our proteomics research include:
- Linking changes in one protein or gene with subsequent effects on many other proteins, to better understand how that protein or gene functions.
- Discovering changes in proteins within cells that explain how the cells function, or how they change in a disease. This may give clues to new treatments.
- Defining proteomic changes that can be used to diagnose a disease, or indicate the best treatment for an individual’s disease. This is one aspect of personalised medicine.
Systems biology
Many changes occurring within cells in health or disease are subtle and complex. Understanding slight changes in a cell’s genetic material (genome), coupled with changes in the proteome, can provide new insights into diseases.
Systems biology brings proteomic and genomic information together. This can be a powerful approach to understanding how diseases occur, and how they may be better diagnosed and treated.
Researchers:
WEHI.TV animation: various DNA molecular visualisations derived from x-ray crystallography and other data sets, and imbued with dynamic movement that suggest brownian motion.
WEHI.TV animation: created for a major trans-national production effort to raise awareness, educate and promote DNA science to the wider community, coinciding with the 50th anniversary of the discovery of the double helix.