Investigating the phagocytosis of dead cells in inflammation

PhD and Graduate Research Masters
Masters by Coursework
Honours

Excessive cell death can cause inflammation. Macrophages play a crucial role in preventing inflammation by phagocytosing dead cells and releasing anti-inflammatory factors. Dysregulation of phagocytosis of dead cells is linked to diseases like lupus, arthritis, and atherosclerosis. However, insufficient knowledge about the signals governing dead cell removal and macrophage reprogramming hampers the regulation of phagocytosis for disease treatment.

In this study, students will employ advanced proteomic techniques, such as phosphoproteomics and spatial proteomics along with functional genetic screens and cell biology techniques to uncover cellular events regulating dead cell phagocytosis and the release of anti-inflammatory cytokines by phagocytosing macrophages.

The Tanzer lab is a dynamic and enthusiastic team that focusses on exploring the body’s response to dead cells within the context of inflammation by employing proteomic approaches, functional genetic screens, and a diverse array of cell biology techniques. By joining the Tanzer lab, students will have the exceptional opportunity to engage in cutting-edge research and apply both global and targeted experimental methods to unravel the intricate mechanisms driving inflammation. This unique position will enable students to contribute to advancements in the field, broaden their scientific expertise, and collaborate closely with a passionate team dedicated to understanding the complex interplay between cell death and inflammation.