Identification of novel CAR T cell brain cancer targets using high throughput synthetic biology omics assays

Project type

  • Masters by Coursework
  • Honours

Project details

Glioblastoma is an aggressive form of brain cancer with limited effective treatment options. Chimeric Antigen Receptor (CAR) T cell therapy, an emerging field involving the engineering of immune cells, holds great potential for the treatment of glioblastoma.

This project will aim to identify novel CAR T cell therapies by applying synthetic biology principles through the use of protein display assays. This project offers an opportunity for students with an interest in synthetic biology, oncology, protein engineering, and genomics to contribute to a significant area of cancer research.

Scientific diagram
Synthetic biology paradigm. Created with BioRender.com

About our research group

The Bowden Laboratory is interested in improving how we study genomes and their organisation and expression, focusing particularly on infection, the study of individual cells and ways to exploit DNA sequencing to develop new treatments for disease.
Our laboratory hosts the WEHI Genomics facility. We support WEHI in accessing all forms of genomics technology, through a comprehensive suite of advanced preparation platforms and sequencing technologies, and a dynamic R&D program that matches WEHI’s areas of scientific focus.

Education pathways