Professor Marc Pellegrini - Infection division

Professor Marc Pellegrini - Infection division

Location: 
Davis Auditorium
Start Time: 
Mon, 25/03/2019 - 12:00pm
End Time: 
Mon, 25/03/2019 - 1:00pm

Growing up in a cell: negotiating host molecular pathways

​Postgraduate lecture series hosted by Dr Greg Ebert

Intracellular microbes love their homes – to a point. They have to evolve mechanisms to preserve their early replicative niche. To this end they could potentially avoid perturbing critical host cellular pathways. However, this is difficult when major cellular machinery is being seconded for microbial expansion. So, they must interface and manipulate host signalling networks to their advantage. Despite the diversity of intracellular pathogens, the same host cell pathways are being utilised to establish reservoirs of infection. The NFkappaB activation pathway is critical for the viral lifecycle of HIV and hepatitis B virus. Different programmed cell death pathways, lytic and non-lytic, are manipulated by numerous pathogens. Non-lytic forms of cell death are antagonised to allow for microbial turnover but subsequently, lytic forms of cell death are promoted to allow for pathogen escape and spread, Mycobacterium tuberculosis has mastered this approach. In an interactive seminar examples will be used to demonstrate these phenomena, hypotheses will be generated in real time and experiments to address them will be designed with a focus on identifying therapeutic strategies.