Professor Katherine Kedzierska, Doherty Institute

Professor Katherine Kedzierska, Doherty Institute

Start Time: 
Wed, 17/03/2021 - 1:00pm
End Time: 
Wed, 17/03/2021 - 2:00pm

WEHI Wednesday Seminar hosted by Professor Phil Hodgkin

Professor Katherine Kedzierska
Laboratory Head, Department of Microbiology & Immunology, University of Melbourne at Doherty Institute

COVID-19: a race between SARS-CoV-2 and immunity

Join via TEAMS
Includes Q&A session

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill-defined. Our analyses of SARS-CoV-2-infected individuals at acute and/or convalescent timepoints quantified 184 immunological parameters. Acute COVID-19 presented with high levels of IL-6, IL-18 and IL-10 and broad activation marked by upregulation of CD38 on innate and adaptive lymphocytes and myeloid cells. Importantly, activated CXCR3+cTFH1 cells in acute COVID-19 significantly correlated with and predicted antibody levels and their avidity at convalescence as well as acute neutralisation activity. Strikingly, intensive care unit (ICU) patients with severe COVID-19 display higher levels of soluble IL-6, IL-6R, IL-18, and hyperactivation of innate, adaptive and myeloid compartments than patients with moderate disease.

Our analyses provide a comprehensive map of longitudinal immunological responses in COVID-19 patients and integrate key cellular pathways of complex immune networks underpinning severe COVID-19, providing important insights into potential biomarkers and immunotherapies.