Professor Katharina Gaus - University of NSW

Professor Katharina Gaus - University of NSW

Location: 
Davis Auditorium
Start Time: 
Mon, 27/03/2017 - 12:00pm
End Time: 
Mon, 27/03/2017 - 1:00pm

What can single molecule localisation microcopy (SMLM) do for you?

​Postgrad lecture series

One would think that nothing is better than imaging single molecule to identify molecular mechanisms in intact and live cells. Indeed, single molecule localisation microscopy (also known as PALM, (d)STORM, GSDIM, PAINT etc.) promises to revolutionise molecular and cell biology as it provides a truly molecular perspective of complex cellular progresses. However, these SMLM approaches do not actually return images but the molecular coordinates of fluorescent events. The challenge now is to figure out how we can utilise these unique data sets to capture for example the functional heterogeneities in receptor signalling. I will provide an overview of the state-of-the-art of SMLM and SMLM data analysis, and illustrate how we use SMLM to better understand T cell signalling.

Scientia Professor Katharina Gaus is an NHMRC Senior Research Fellow at the University of New South Wales and Head of the EMBL Australia Node in Single Molecule Science. She received her PhD from the University of Cambridge in 1999 and has led an independent research group since 2005. Her group investigates signal transduction processes in T lymphocytes with advanced fluorescence microscopy approaches. She was awarded the Young Investigator Award from the Australia and New Zealand Society for Cell and Developmental Biology (2010), the Gottschalk Medal from the Australian Academy of Science (2012) and the New South Wales Science and Engineering Award for Excellence in Biological Sciences (2013).