Professor Jacob Corn - Innovative Genomics Initiative and University of California, Berkley

Professor Jacob Corn - Innovative Genomics Initiative and University of California, Berkley

Location: 
Seminar Room 1
Start Time: 
Wed, 15/02/2017 - 11:00am
End Time: 
Wed, 15/02/2017 - 12:00pm

​CRISPR/Cas9 from mechanism to therapy

​Special seminar hosted by Dr Marco Herold

Genome editing tools, exemplified by CRISPR-Cas nucleases such as Cas9, are fundamentally DNA damaging agents. Hence, they are inextricably linked to DNA repair in that they represent new opportunities to study the biology of DNA repair in human cells and intensify the urgency of studying these processes. CRISPR-mediated genome engineering is currently a mostly empiric process, requiring extensive testing and frequent failure. This is especially the case for the introduction or replacement of genomic sequences. Yet most genetic diseases can only be cured through sequence replacement approaches, leaving genome editors unable to change the course of these disorders. Professor Corn and his lab focuses on using and developing genome perturbation tools to better understand the DNA repair mechanisms underlying genome editing and the use of these tools to cure orphan genetic disorders.

Jacob Corn is the Scientific Director of the Innovative Genomics Initiative (IGI)  at UC Berkeley and is committed to the improvement of human health through the fundamental understanding of disease mechanisms. Over the last fifteen years he has bridged academia and industry, working in therapeutic areas that include infectious disease, neurobiology, and oncology. His work at the IGI aims to bring about the end of genetic disease through the development and application of next-generation genome editing technologies.