Professor Ivo Mueller - Population Health and Immunity division

Professor Ivo Mueller - Population Health and Immunity division

Location: 
Davis Auditorium
Start Time: 
Wed, 09/10/2019 - 1:00pm
End Time: 
Wed, 09/10/2019 - 2:00pm

Elimination of P. vivax malaria – challenges, opportunities and novel approaches

Wednesday seminar​

Professor Ivo Mueller is a malaria epidemiologist, jointly appointed as Co-Division Head of the Population Health and Immunity division at The Walter and Eliza Hall Institute of Medical Research and Head of the Malaria Parasites and Hosts Laboratory in the Department of Parasites and Insect Vectors at The Institut Pasteur in Paris.

All countries in the Asia-Pacific region have committed themselves to eliminating malaria by 2030. A major challenge to this ambitious goal is the high prevalence of P. vivax in our region, a parasite which seems to be more resistant to classical malaria control measure. The main reason for this increased resilience to control is its ability to relapse from long-lasting, clinically silent liverstages. These hypnozoite cannot be directly diagnosed and the only currently available treatments can cause severe haemolysis in people with G6PD-deficiency. Using a mathematical model of P. vivax transmission, we demonstrated that effective detection and treatment of dormant liverstages infections is key to achieving P. vivax elimination and propose a novel way to detect hypnozoite carriers through the determination of an immune signature characteristic of recent exposure to P. vivax infection.