Professor Grant McArthur - Peter MacCallum Cancer Centre

Professor Grant McArthur - Peter MacCallum Cancer Centre

Davis Auditorium
Start Time: 
Mon, 23/05/2016 - 12:00pm
End Time: 
Mon, 23/05/2016 - 1:00pm

The interface between immune checkpoint inhibitors and targeted therapies in melanoma

Postgrad lecture series

The disease of melanoma has seen dramatic advances in outcomes for patients with advanced disease through the development of therapies targeting either the BRAF oncogene or immune checkpoints in T-lymphocytes. Targeting signalling activated by mutant BRAF causes tumour regression in over 90% of patients but resistance developments in the majority of patients.  In contrast targeting immune checkpoints benefits 50% or fewer patients but the responses are often durable.  The scientific rationale and challenges in combining these therapies will be discussed as Grant aspires for long term disease control in one of the most aggressive of metastatic cancers.

Professor Grant McArthur is a physician scientist with research interests in targeting oncogenes and clinical trials in melanoma.  He is the Lorenzo Galli Chair in Melanoma and Skin Cancers at the University of Melbourne and the Director of the Skin Cancer and Melanoma Tumour Stream of the VCCC Parkville.