Professor Eric Eldering - Academic Medical Center, The Netherlands

Professor Eric Eldering - Academic Medical Center, The Netherlands

Location: 
Davis Auditorium
Start Time: 
Thu, 03/09/2015 - 1:00pm
End Time: 
Thu, 03/09/2015 - 2:00pm

​From the dark zone into the light; the Bcl-2 juggle in the Germinal Center

​Special Seminar Series

Professor Eldering and his laboratory investigates apoptosis regulation in normal and pathological immune cells. Currently, there are two main lines of research. First, hemato-oncology mainly focused on Chronic Lymphocytic Leukemia (CLL), together with the Dept of Hematology (Professors Arnon Kater and Rien van Oers). These fundamental and translational studies focus on novel treatment strategies that circumvent microenvironmental- and p53-induced chemoresistance. They focus their research on BH3 mimetics, kinase inhibitors and anti-CD20 antibodies. More recently, we started biochemical and genetic analyses of (novel) cancer mutations in CLL such as TP53, ATM, SF3B1 and Notch1. A second research line focuses on how apoptosis regulators shape the immune response. They have uncovered a novel role for the Bcl-2 family members Noxa and Mcl-1 in selection of the fittest antigen-responsive clones from the naïve lymphocyte pool. Currently Eric and his team study Bcl-2 family members in the context of B cell activation, effector and memory T cell formation, and changes in cellular metabolism. This seminar will focus on 1) the division of labor among Bcl-2 members in the human GC, and 2) BCR+BAFF signaling to Mcl-1 regulation as affinity threshold for GC selection.