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- Analysis and reporting of whole genome sequencing data from malaria parasites
- Analysis of long read data from the minION, with application to malaria
- Analysis of short tandem repeat markers from whole genome sequencing
- Antibody longevity following Plasmodium vivax infections
- Antigenic diversity of malaria parasites: towards more effective malaria vaccines
- Biogenesis of eosinophil granules
- Biological sequence analysis and genomic variant discovery
- Biology of the unique intra-mitochondrial bacterium Midichloria mitochondrii
- Characterising regulatory T cells in coeliac disease
- Chemical probing to identify effectors of necroptotic cell death
- Computational systems biology of Wnt/cell adhesion signalling in colon cancer
- Controlling apoptotic cell death in cancer
- Deciphering mechanisms of thrombocytopenia (low platelet count) in blood cancers
- Developing non-invasive methods to monitor kidney transplant rejection
- Discovery and analysis of autoimmune regulators
- Drug targets and compounds that block growth of malaria parasites
- Dying to survive: mechanistic insights into human bowel cancer development
- Dynamic discovery of innate immunity through imaging and genomics
- Dysregulation of TNF expression in inflammatory diseases
- Elucidation of long range methylation structure using nanopore sequencing
- Eosinophil activation
- Eosinophil death
- Eosinophil heterogeneity
- Eosinophil maturation
- Epigenetic regulation of the immune system
- Explosive cell death and human disease
- Export of malaria virulence proteins during liver infection
- Function of proteins involved in invasion of erythrocytes by malaria parasites
- Functional genomics to improve therapeutic options for rare cancers
- Giardia duodenalis phosphoproteome and protein kinase network
- Harnessing the immune system to target small cell lung cancer
- How do malaria parasites traverse human cells and invade hepatocytes?
- How does the malaria parasite prevent the host liver cell from dying?
- Human monoclonal antibodies against malaria infection
- IL5 signalling in asthma
- Identification of genes critical for the control of chronic infections
- Identification of malaria parasite entry receptors
- Identifying new cell death and inflammatory pathways
- Identifying proteome signatures of high grade glioma for precision medicine
- Investigating apoptosis control in tumour blood vessels
- Investigating brain abnormalities with single cell ‘omics
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating the molecular regulation of neovascular eye disease
- Long-read sequencing for transcriptome and epigenome analysis
- Machine learning analysis of mutagenesis datasets
- Macro-evolution in cancer
- Mapping human gene mutations affecting anti-malarial drug efficacy
- Mechanism and modulation of K+ channels and membrane transporters
- Mechanisms of disease relapse in acute lymphoblastic leukaemia
- Microbiome analysis using long read nanopore sequencing
- Molecular mechanism underpinning dendritic cell ontogeny and functions
- Molecular mechanisms of innate immune signalling
- Next-generation mucolytics to treat lung diseases
- No sex please, we’re inhibited: searching for drugs to prevent malaria transmission
- Novel biomarkers and mechanisms of antimalarial drug resistance
- Novel real-time, quantitative imaging approaches for studying malaria
- Novel regulators of JAK-STAT signalling in development and disease
- Novel tool for malaria surveillance and intervention
- Optimising serological markers of recent exposure to Plasmodium vivax
- Quantitation of human T cell responses in primary immunodeficiency
- Reconciling intracellular imaging and metastatic behaviour in cancer cells
- Reconstructing the immune response: from molecules to cells to systems
- Role of protein glycosylation in malaria virulence
- Statistical bioinformatic analyses of RNA-seq and ChIP-seq data
- Strategies mammalian cells use to survive without growth factors
- Structural and biochemical studies on Notch signal transduction
- Structural and functional analysis of malaria invasion
- Structural biology and binding studies of BCL-2 family proteins
- Structural studies of invasion processes during malaria infection
- Structural studies of the Plasmodium and Toxoplasma tight-junction complex
- Target identification of potent antimalarial agents
- The role of glycosylation in malaria vaccine design
- Towards a molecular description of plasma cell diversity
- Tracking the spread of malaria in the Asia Pacific region
- Transmembrane control of type I cytokine receptor activation
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding resistance to apoptotic cell death
- Understanding the common through study of the rare
- Understanding the development of humoral immunity to malaria
- Unravelling cellular circuitry with single cell RNA-seq and CRISPR
- Unravelling the molecular architecture of killer T cells in disease
- Why is interleukin-11 elevated in acute myeloid leukaemia?
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Leanne Robinson-Projects
Researcher:
Relapsing P. vivax infections in Papua New Guinean children
Plasmodium vivax has the ability to cause relapsing infections from long-lasting liver stages called hypnozoites. By studying the effect of removing long lasting liver-stages with primaquine treatment on the subsequent risk of P. vivax infection and illness, we have demonstrated that relapses cause around 80 per cent of P. vivax infections in PNG children and are important in sustaining transmission.
Data from these cohort studies is also being used to develop mathematical models of P. vivax relapses to predict the effectiveness of various intervention strategies against P. vivax and study within host, clonal dynamics.
Impact of malaria control on the epidemiology and transmission of P. falciparum and P. vivax malaria in Papua New Guinea
The intensification of the PNG malaria control program over the past 10 years is significantly reducing the burden of malaria and changing the complex relationships between parasites, human hosts and mosquito vectors.
Through a series of repeated community cross-sectional surveys, longitudinal child cohort studies, entomological surveys and hospital-based surveillance in two endemic areas of the country, we are using sensitive molecular diagnostics to monitor the impact of these changes on the age-specific burden of malaria, the natural acquisition of immunity, behavior of vectors and risk factors for infection and transmission, so as to be able to inform ongoing and future control efforts.
The dynamics of malaria transmission stages in host and vector
This study aims to determine the risk factors for Plasmodium spp. gametocyte carriage and study the temporal associations between the presence and complexity of asexual and sexual Plasmodium spp. infections. In parallel, the study will investigate the relationship between the presence and density of gametocyte in a blood samples and its infectivity to local vectors by conducting a series of standard mosquito membrane feeding assays.
Knowledge of the gametocyte carriers in a population, when gametocytes are most prevalent, and what are the determinants of infectivity to the mosquito vector, is essential for improving the implementation of current control tools and informing the development of novel interventions aimed at the interruption of local transmission.
Natural acquisition of immunity to P. falciparum and P. vivax in pregnancy, infancy and childhood
Our understanding of antibody and cellular immune responses that underpin the development of natural immunity to malaria is still evolving. Utilising samples collected during longitudinal cohort studies of pregnant women, infants and children in Madang and Maprik areas of PNG, we are investigating the dynamics of antibody and cellular immune responses, their acquisition, suppression, boosting and maintenance.
In addition, we are investigating trans-placental transfer of antibodies to infectious diseases and the role of pre-natal malaria exposure on immune responses and all-cause morbidity during infancy.
