Selected Publications

1. Mweempwa, A., Rosenthal, M, A., Dimou, J., Drummond, K, J., & WHITTLE, J, R. (2021) Perioperative clinical trials for glioma: raising the bar. Journal of Clinical Neuroscience. Senior and corresponding author PMID: 34119258
2. WHITTLE, J, R., Vaillant, F., Surgeon, E., Policheni, A., Giner, G., Capaldo, B, D., Chen, H., Liu, H, K., Dekkers, J, F., Sachs, N., Clevers, H., Fellowes, A., Green, T., Xu, H., Fox, S, B., Herold, M, J., Smyth, G, K., Gray, D, H, D., Visvader, J, E., and Lindeman, G, J (2020). Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer. Clinical Cancer Research. doi: 10.1158/1078-0432.CCR-19-1872. PMID: 32245900
3. Dekkers, J, F.,* WHITTLE, J, R.,* Vaillant, F., Chen, H., Dawson, C., Liu, K., Geurts, M, H., Herold, M, J., Clevers, H., Lindeman, G, J., and Visvader J, E. (2020) Modelling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids. Journal of the National Cancer Institute, 112(5), 540 – 544. doi: 10.1093/jnci/djz196. * equal contribution. PMID: 31589320
4. Lok, S, W.,* WHITTLE, J, R.,* Vaillant, F., Teh, C., Lo, L, L., Policheni, A, N., Bergin, A, R, T., Desai, J., Ftouni, S., Gandolfo, L, C., Liew, D., Liu, H, K., Mann, G, B., Moodie, K., Murugasu, A., Pal, B., Roberts, A, W., Rosenthal, M, A., Shacleton, K., Silva, M, J., Siow, Z, R., Smyth, G, K., Taylor, L., Travers, A., Yeo, B., Yeung, M, M., Bujak, A, Z., Dawson, S, J., Gray, D, H, D., Visvader, J, E., and Lindeman, G, J. (2019) A phase Ib dose-escalation and expansion study of the BCL2 inhibitor venetoclax combined with tamoxifen in ER and BCL2–positive metastatic breast cancer. Cancer Discovery, 9(3), 354 – 369. (doi: 10.1158/2159-8290.CD-18-1151). (IF 26.3370; Citations 53). * equal contribution. PMID: 30518523
5. Merino, D.*, WHITTLE, J, R.,* Vaillant, F.,* Serrano, A., Gong, J., Giner, G., Maragno, A, L., Scheider, E., Pal, B., Li, X., Dewson, G., Grasel, J., Liu, K., Lalaoui, N., Segal, D., Herold, M., Huang, D., Smyth, G., Geneste, O., Lessene, G., Visvader, J, E., and Lindeman, G, J. (2017) Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple- negative and HER2-amplified breast cancer. Science Translational Medicine, 9(401). (doi: 10.1126/scitranslmed.aam7049). * equal contribution. PMID: 28768804
6. WHITTLE, J, R. Lickliter, J, D., Gan, H, K., Scott, A, M., Simes, J... and Rosenthal, M. First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma. (2015), Journal of Clinical Neuroscience, 22(12): 1889 – 94. (10.1016/j.jocn.2015.06.005).  PMID: 26279503