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- A complete cure for HBV
- A stable efficacious Toxoplasma vaccine
- Activating SMCHD1 to treat FSHD
- Fut8 Sugar coating immuno oncology
- Improving vision outcomes in retinal detachment
- Intercepting inflammation with RIPK2 inhibitors
- Novel inhibitors for the treatment of lupus
- Novel malaria vaccine
- Novel therapy for drug-resistant cancers
- Precision epigenetics silencing SMCHD1 to treat Prader Willi Syndrome
- Rethinking CD52 a therapy for autoimmune disease
- Selective JAK inhibition: mimicking SOCS activity
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- Anne-Laure Puaux
- Associate Professor Aaron Jex
- Associate Professor Alyssa Barry
- Associate Professor Andrew Webb
- Associate Professor Anne Voss
- Associate Professor Chris Tonkin
- Associate Professor Daniel Gray
- Associate Professor Edwin Hawkins
- Associate Professor Ethan Goddard-Borger
- Associate Professor Grant Dewson
- Associate Professor Isabelle Lucet
- Associate Professor James Murphy
- Associate Professor Jeanne Tie
- Associate Professor Jeff Babon
- Associate Professor Joan Heath
- Associate Professor Justin Boddey
- Associate Professor Marco Herold Marco Herold
- Associate Professor Marie-Liesse Asselin-Labat
- Associate Professor Marnie Blewitt
- Associate Professor Matthew Ritchie
- Associate Professor Melissa Davis
- Associate Professor Oliver Sieber
- Associate Professor Peter Czabotar
- Associate Professor Rachel Wong
- Associate Professor Ruth Kluck
- Associate Professor Sandra Nicholson
- Associate Professor Seth Masters
- Associate Professor Sumitra Ananda
- Associate Professor Tim Thomas
- Associate Professor Wai-Hong Tham
- Associate Professor Wei Shi
- Catherine Parker
- Dr Anna Coussens
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- Dr Ben Tran
- Dr Bernhard Lechtenberg
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- Dr Brad Sleebs
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- Dr Drew Berry
- Dr Emma Josefsson
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- Dr Gwo Yaw Ho
- Dr Hui-Li Wong
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- Dr Ian Majewski
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- Dr Kelly Rogers
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- Dr Lucy Gately
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- Dr Maryam Rashidi
- Dr Matthew Call
- Dr Melissa Call
- Dr Misty Jenkins
- Dr Philippe Bouillet
- Dr Rebecca Feltham
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- Dr Samir Taoudi
- Dr Sant-Rayn Pasricha
- Dr Shalin Naik
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- Professor Lynn Corcoran
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- Professor Nicos Nicola
- Professor Peter Colman
- Professor Peter Gibbs
- Professor Phil Hodgkin
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- Professor Terry Speed
- Professor Tony Burgess
- Professor Tony Papenfuss
- Professor Warren Alexander
- Diseases
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- Student research projects
- 6 cysteine proteins key mediators between malaria parasites and human host
- A balancing act of immunity: autoimmunity versus malignancies
- Activating https://www.wehi.edu.au/node/add/individual-student-research-page#Parkin to treat Parkinson’s disease
- Analysing single cell technologies to understand breast cancer
- Bioinformatics methods for detecting and making sense of somatic genomic rearrangements
- Characterising new regulators in inflammatory signalling pathways
- Computational melanoma genomics
- Control of human lymphocyte cell expansion in complex immune diseases
- Deciphering biophysical changes in red blood cell membrane during malaria parasite infection
- Deciphering the signalling functions of pseudokinases
- Deep profiling of blood cancers during targeted therapy
- Determining the mechanism of type I cytokine receptor triggering
- Differential expression analysis of RNA-seq using multivariate variance modelling
- Discovering new genetic causes of primary antibody deficiencies
- Discovery of novel drug combinations for the treatment of bowel cancer
- Drug targets and compounds that block growth of malaria parasites
- Effects of nutrition on immunity and infection in Asia and Africa
- Enabling deubiquitinase drug discovery
- Epigenetic drivers of immune cell function
- Epigenetic regulation of systemic iron homeostasis
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Fatal attraction: how apoptotic pore assembly is governed during mitochondrial cell death
- Genomic instability and the immune microenvironment in lung cancer
- How do T lymphocytes decide their fate?
- How the epigenetic regulator SMCHD1 works and how to target it to treat disease
- Human lung protective immunity to tuberculosis: host-environment systems biology
- Human monoclonal antibodies against malaria infection
- Identifying novel treatment options for ovarian carcinosarcoma
- Inflammasome activation in autoinflammatory disease
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating microbial natural products with anti-protozoal activity
- Investigating the role of mutant p53 in cancer
- Investigating the role of platelets in motor neuron disease
- Mapping DNA repair networks in cancer
- Molecular mechanisms controlling embryonic lung progenitor cells
- Nanobodies against malaria
- Neutrophil heterogeneity in inflammation
- New approaches to treat cancer and inflammatory disease using the ubiquitin system
- Next generation CRISPR screens using iPSC
- Novel cell death and inflammatory modulators in lupus
- Programming T cells to defend against infections
- Restraining cytokine-receptor signalling in myeloproliferative neoplasms
- Screening for regulators of jumping genes
- Statistical analysis of genome-wide chromatin organisation using Hi-C
- Statistical analysis of trapped-ion-mobility time-of-flight mass spectrometry proteomics data
- Structure and function of E3 ubiquitin ligases
- Target identification of potent antimalarial agents
- The mitochondrial TOM complex in neurodegenerative disease
- The molecular mechanisms underlying Kir4.1 activity in gliomas
- The role of differential splicing in the genesis of breast cancer
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding malaria infection dynamics
- Understanding the function of the E3 ligase Parkin in Parkinson’s disease
- Understanding the molecular basis of chromosome instability in gastric cancer
- Utilising pre-clinical models to discover novel therapies for tuberculosis
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- Renewed support for HIV eradication project
- Searching for solutions to muscular dystrophy
- Supporting research into better treatments for colon cancer
- Taking a single cell focus with the DROP-seq
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Ian Street-publications
Researcher:
Publications
- Brady, R. M.; Vom, A.; Roy, M. J.; Toovey, N.; Smith, B. J.; Moss, R. M.; Hatzis, E.; Huang, D. C. S.; Parisot, J. P.; Yang, H.; Street, I. P.; Colman, P. M.; Czabotar, P. E.; Baell, J. B.; Lessene, G. De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization. J. Med. Chem. 2014, 57, 1323–1343. PMID:24456288
- Lackovic, K., Falk, H. Leuchowius, K. Lessene, G., Baell J. & Street I. A Perspective on 10-Years HTS Experience at the Walter and Eliza Hall Institute of Medical Research – Eighteen Million Assays and Counting. Combinatorial Chemistry and High Throughput Screening. 2014, 17(3):241-252. PMID: 24409955
- Zhang, L.; Holmes, I. P.; Hochgräfe, F.; Walker, S. R.; Ali, N. A.; Humphrey, E. S.; Wu, J.; de Silva, M.; Kersten, W. J. A.; Connor, T.; Falk, H.; Lynda, A.; Street, I. P.; D., B. J.; Pilling, P.; Monahan, B. J.; Peat, T. S.; Daly, R. J. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J. Proteome 2013, 12, 3104–3116. PMID: 23692254
- Lessene, G.; Czabotar, P. E.; Sleebs, B. E.; Zobel, K.; Lowes, K. N.; Adams, J. M.; Baell, J. B.; Colman, P. M.; Deshayes, K.; Fairbrother, W. J.; Flygare, J. a; Gibbons, P.; Kersten, W. J. A; Kulasegaram, S.; Moss, R. M.; Parisot, J. P.; Smith, B. J.; Street, I. P.; Yang, H.; Huang, D. C. S.; Watson, K. G. Structure-guided design of a selective BCL-X(L) inhibitor. Nat. Chem. Biol. 2013, 9, 390–7. PMID:23603658.
- Li, R.; Doherty, J.; Antonipillai, J.; Chen, S.; Devlin, M.; Visser, K.; Baell, J.; Street, I.; Anderson, R. L.; Bernard, O. LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice. Clin. Exp. Metastasis 2013, 30, 483–95. PMID: 23239465
- Willoughby, L. F.; Schlosser, T.; Manning, S. A.; Parisot, J. P.; Street, I. P.; Richardson, H. E.; Humbert, P. O.; Brumby, A. M. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Dis. Model. Mech. 2013, 6, 521–529. PMID: 22996645.
- Sleebs, B.E., P.E. Czabotar, W.J. Fairbrother, W.D. Fairlie, J.A. Flygare, D.C.S. Huang, W.J.A. Kersten, M.F.T. Koehler, G. Lessene, K. Lowes, J.P. Parisot, B.J. Smith, M.L. Smith, A.J. Souers, I.P. Street, H. Yang, and J.B. Baell, Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity. Journal of Medicinal Chemistry, 2011. 54(6): p. 1914-1926. PMID: 21366295.
- Patterson, S., M.S. Alphey, D.C. Jones, E.J. Shanks, I.P. Street, J.A. Frearson, P.G. Wyatt, I.H. Gilbert, and A.H. Fairlamb, Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis and Characterization of their Binding Mode by Protein Crystallography. Journal of Medicinal Chemistry, 2011: 13; 54(19):6514-30. PMID: 21851087
- Sleebs, B.E., G. Nikolakopoulos, I.P. Street, H. Falk, and J.B. Baell, Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2011; 21(19):5992-4. PMID: 21852129.
- Falk, H., T. Connor, H. Yang, K.J. Loft, R.N. Surjadi, J.D. Bentley, M.K. Hattarki, O. Dolezal, J.M. Murphy, B.J. Monahan, T.S. Peat, T. Thomas, J.B. Baell, J.P. Parisot, and I.P. Street, An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets. Journal of Biomolecular Screening, 2011; 16(10):1196-205. PMID: PMID:22086725