Publications

1. Brady, R. M.; Vom, A.; Roy, M. J.; Toovey, N.; Smith, B. J.; Moss, R. M.; Hatzis, E.; Huang, D. C. S.; Parisot, J. P.; Yang, H.; Street, I. P.; Colman, P. M.; Czabotar, P. E.; Baell, J. B.; Lessene, G. De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization. J. Med. Chem. 2014, 57, 1323–1343. PMID:24456288
2. Lackovic, K., Falk, H. Leuchowius, K. Lessene, G., Baell J. & Street I. A Perspective on 10-Years HTS Experience at the Walter and Eliza Hall Institute of Medical Research – Eighteen Million Assays and Counting.  Combinatorial Chemistry and High Throughput Screening. 2014, 17(3):241-252. PMID: 24409955
3. Zhang, L.; Holmes, I. P.; Hochgräfe, F.; Walker, S. R.; Ali, N. A.; Humphrey, E. S.; Wu, J.; de Silva, M.; Kersten, W. J. A.; Connor, T.; Falk, H.; Lynda, A.; Street, I. P.; D., B. J.; Pilling, P.; Monahan, B. J.; Peat, T. S.; Daly, R. J. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J. Proteome 2013, 12, 3104–3116. PMID: 23692254 
4. Lessene, G.; Czabotar, P. E.; Sleebs, B. E.; Zobel, K.; Lowes, K. N.; Adams, J. M.; Baell, J. B.; Colman, P. M.; Deshayes, K.; Fairbrother, W. J.; Flygare, J. a; Gibbons, P.; Kersten, W. J. A; Kulasegaram, S.; Moss, R. M.; Parisot, J. P.; Smith, B. J.; Street, I. P.; Yang, H.; Huang, D. C. S.; Watson, K. G. Structure-guided design of a selective BCL-X(L) inhibitor. Nat. Chem. Biol. 2013, 9, 390–7. PMID:23603658.
5. Li, R.; Doherty, J.; Antonipillai, J.; Chen, S.; Devlin, M.; Visser, K.; Baell, J.; Street, I.; Anderson, R. L.; Bernard, O. LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice. Clin. Exp. Metastasis 2013, 30, 483–95. PMID: 23239465
6. Willoughby, L. F.; Schlosser, T.; Manning, S. A.; Parisot, J. P.; Street, I. P.; Richardson, H. E.; Humbert, P. O.; Brumby, A. M. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Dis. Model. Mech. 2013, 6, 521–529. PMID: 22996645. 
7. Sleebs, B.E., P.E. Czabotar, W.J. Fairbrother, W.D. Fairlie, J.A. Flygare, D.C.S. Huang, W.J.A. Kersten, M.F.T. Koehler, G. Lessene, K. Lowes, J.P. Parisot, B.J. Smith, M.L. Smith, A.J. Souers, I.P. Street, H. Yang, and J.B. Baell, Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity. Journal of Medicinal Chemistry, 2011. 54(6): p. 1914-1926. PMID: 21366295.
8. Patterson, S., M.S. Alphey, D.C. Jones, E.J. Shanks, I.P. Street, J.A. Frearson, P.G. Wyatt, I.H. Gilbert, and A.H. Fairlamb, Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis and Characterization of their Binding Mode by Protein Crystallography. Journal of Medicinal Chemistry, 2011: 13; 54(19):6514-30. PMID: 21851087
9. Sleebs, B.E., G. Nikolakopoulos, I.P. Street, H. Falk, and J.B. Baell, Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2011; 21(19):5992-4. PMID: 21852129. 
10. Falk, H., T. Connor, H. Yang, K.J. Loft, R.N. Surjadi, J.D. Bentley, M.K. Hattarki, O. Dolezal, J.M. Murphy, B.J. Monahan, T.S. Peat, T. Thomas, J.B. Baell, J.P. Parisot, and I.P. Street, An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets. Journal of Biomolecular Screening, 2011; 16(10):1196-205. PMID: PMID:22086725