Ms Suad Abdirahman - Inflammation division

Ms Suad Abdirahman - Inflammation division

Location: 
Davis Auditorium
Start Time: 
Mon, 15/04/2019 - 3:00pm
End Time: 
Mon, 15/04/2019 - 4:00pm

New pre-clinical models of colorectal cancer

​PhD Completion seminar

Colorectal cancer (CRC) is the third most common cancer worldwide, and is one of the most commonly occurring cancers in Australia. When detected early, CRC is treatable; however, patients often relapse and ultimately succumb to metastatic disease. Despite many advances in treatment options, chemotherapy response rates for advanced CRC remain low, primarily due to the development of resistance.

During her PhD, Suad has established and characterised a cohort of CRC patient-derived xenografts (PDX) and demonstrated that these models recapitulated the general features and the heterogeneity of the patient tumours from which they were derived. She also generated four 5-Fluorouracil (5-FU) resistant PDX sub-lines, and found that they exhibited increased epithelial Interleukin (IL)-11R expression, with additional changes in IL-11 expression attributed to the tumour microenvironment. Her studies implicate IL-11 mediated STAT3 activation as a mechanism that contributes to chemoresistance.