Miss Maria Bergamasco - Epigenetics and Development division

Miss Maria Bergamasco - Epigenetics and Development division

Davis Auditorium
Start Time: 
Wed, 16/10/2019 - 1:00pm
End Time: 
Wed, 16/10/2019 - 2:00pm

The roles of the histone acetyltransferase, KAT6B, in neural stem cells and cortex development

​Wednesday seminar  (this is a PhD confirmation seminar) hosted by Associate Professor Anne Voss

In eukaryotic cells, DNA exists in association with histones to form chromatin, the organisation of which regulates gene expression. Coordinated gene activity underlies cell identify and is crucial in ensuring that biological systems develop normally. This is highly relevant within the mammalian brain, which expresses approximately 80% of all genes. As such, regulators of chromatin structure and gene expression are of vital importance during cortical development, with their mutation or dysregulation seen to result in brain malformations and intellectual disability.

One such regulator, the MYST family histone lysine acetyltransferase, KAT6B, is mutated in human intellectual disability disorders and has been identified as a driver of neural stem cell potency and proliferation. This talk will focus on the contributions of KAT6B to brain development, as well as its molecular mechanism within neural stem cells and the developing cortex, assessing the consequences of both loss of KAT6B and its overexpression.