Mass Spectrometry Specialist

Mass Spectrometry Specialist

Application closing date: 
Thu, 05/11/2020 - 5:00pm

About the position

We are looking for an enthusiastic and self-directed person to bring their mass spectrometry expertise and establish this powerful and exciting technology in the National Drug Discovery Centre (NDDC) Screening Laboratory. A new full-time position is available for an experienced mass spectrometrist to oversee the implementation of MS-based high-throughput drug screening capability within the NDDC.

The successful candidate will be responsible for setup of a newly acquired Sciex Echo® MS instrument and will implement high-throughput mass spectrometry to support hit identification and lead optimisation and helping to advance the discovery of small molecule medicines.

Responsibilities included, but not limited to:

  • Oversee the implementation and development of mass spectrometry-based high throughput screening capability within the Centre.
  • Provide high-throughput mass spectrometry expertise and coordinate activities to support internal programs and external collaborations.
  • Design experiments for hit identification and collaborate with screening scientists on development of HTS assays.
  • Develop new or improved methods for robust, reproducible, and quantitative MS analysis of biological samples.
  • Perform direct binding and mechanism-of-action studies on validated hits.
  • Establishment of instrument performance benchmarks
  • Provide upkeep and maintenance of instrumentation with a strong ability to troubleshoot.
  • Explore and develop new technologies applicable to drug discovery.

Selection Criteria

  • BSc or postgraduate degree in analytical chemistry or related field, or an equivalent combination of knowledge and experience
  • Substantial demonstrated laboratory research experience
  • Extensive experience and expertise operating and maintaining mass spectrometry equipment
  • Demonstrated expert level range of MS techniques (in particular, familiarity with triple quadrupole mass spectrometry, MSn, and electrospray ionisation would be highly regarded)
  • Experience in all aspects of mass spectrometry experiments including sample preparation, mass spectrometer operation, interpretation of spectra, quantitative analysis and validation of methodology
  • Ability to contribute to problem solving and the establishment of new techniques
  • Sound computer skills and ability to accurately record data, results and the development of new methods and theories
  • Project management, excellent oral and written communication and reporting skills

Terms of appointment

This position is available for 1 year in a full-time capacity. Salary is HEW 8 ($102,193-$110,611). Up to 17% superannuation and very attractive salary packaging options are available.

General enquiries can be directed to Kym Lowes on

A position description is attached.  

How to apply

Please email your application including cover letter, CV and a letter addressing the key selection criteria in pdf format to, quoting reference WEHI/ANKL071020 in the subject line.

Application closing date:  5 November 2020

At the Walter and Eliza Hall Institute we strive to ensure our staff and students enjoy a great working environment.  We value diversity and gender equity in our work force and promote flexible working arrangements for staff to balance working requirements and personal needs. We have implemented a number of gender equity initiatives to support female laboratory heads.