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Inflammasomes & Autoinflammatory Disease Laboratory

About the lab

Our laboratory studies inflammation generated by the innate immune system. This can happen in many different contexts, including during infection, when cells die, or when genetic mutations activate innate immune pathways causing autoinflammatory disease. Inflammation contributes to the development of many chronic inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease, amyotrophic lateral sclerosis (ALS) and type 2 diabetes.

Previously we have made discoveries relevant to all of these areas. We maintain close links to industry and the clinic to make sure our discoveries can continue to have a direct effect on human health in the future.

Impact

The Masters laboratory has helped discover pathways that drive autoinflammatory disease. For example, we found that an immune sensor called PKR is activated due to proteasome deficiency, and we found that the cytokine G-CSF contributes to inflammatory pathology in the condition APLAID.

We continue trying to find the genetic causes of autoinflammation through the Australian Autoinflammatory Disease Registry (AADRY.org).

View all publications

Lab research projects

Lab team

We collaborate with many external research groups, including:

Luke O’Neill, Trinity College Dublin; Daniel Kastner, Ivona Aksentijevich and Raphaela Goldbach-Masnky, National Institutes of Health; Eicke Latz and Matthias Geyer, University of Bonn; Dr Bruno Reversade and Franklin Zhoug, Singapore; Andrew Murphy, Baker IDI; Mike Rogers, Garvan Institute; Richard Ferrero, Monash University; Kate Schroder and Kate Stacey, University of Queensland.

4 members
Research Officer
June Sun
Research Assistant
Klara Kong
Research Assistant
Annemarie Steiner
Research Officer
Interested in supporting our research?

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