Yi-Wei Chang – University of Pennsylvania

16/02/2024 2:00 pm - 16/02/2024 3:00 pm
Davis Auditorium

WEHI Director’s Seminar hosted by Associate Professor Chris Tonkin

Yi-Wei Chang, PhD
Assistant Professor of Biochemistry and Biophysics

Associate Director of the Institute of Structural Biology

University of Pennsylvania


Cryo-electron tomography of apicomplexan parasites


Davis Auditorium

Join via TEAMS

Including Q&A session


Yi-Wei Chang is an Assistant Professor of Biochemistry and Biophysics and the Associate Director of the Institute of Structural Biology at the University of Pennsylvania Perelman School of Medicine in the United States. Yi-Wei received his PhD in structural biology from the National Tsing-Hua University and Academia Sinica in Taiwan. He was then trained with Grant Jensen at the California Institute of Technology as a postdoc using cryo-electron tomography to study macromolecular structures and mechanisms in the cellular context.


Since establishing his laboratory in 2019, Yi-Wei has been dedicated to advancing the field of cellular structural biology. His research primarily centers around the application and enhancement of cryo-electron tomography, with a special emphasis on understanding host-pathogen interactions. In this presentation, Yi-Wei will showcase how cryo-electron tomography has facilitated the generation of new structural insights into the rhoptry secretion system and F-actin biogenesis in apicomplexan parasites – both are critical components for host invasion. Additionally, he will elaborate on the ongoing efforts to employ cryo-electron tomography in studying these important structures and their underlaying mechanisms at the host-parasite interface during infection.


All welcome!

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