WEHI Special PHI Seminar hosted by Professor Sant-Rayn Pasricha
Professor Alexander (Hal) Drakesmith Professor of Iron Biology | MRC Investigator; Medical Research Council Human Immunology Unit; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliff Hospital, UK
Iron is required for erythropoiesis but it is increasingly evident that iron and immunity have a critical and interdependent relationship too. Here, I will explain how an underappreciated but vital role for iron in immune responses has become apparent and explore the molecular and metabolic mechanisms underlying the iron-immune connection. I will expand on how basic and pre-clinical work has been translated to clinical trials to study effects of iron on anaemia, haematopoiesis, vaccine responses and human systems immunology.
Hal Drakesmith is Professor of Iron Biology at the MRC Human Immunology Unit in the MRC Weatherall Institute of Molecular Medicine, University of Oxford. Hal was trained at the University of Cambridge, University of Kyoto, and University College London before moving to Oxford. His laboratory works on the interaction of iron homeostasis with immunity, infection, anaemia, and inflammation, with a particular focus on the role of the iron regulatory hormone, hepcidin.