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Professor Forest White – Koch Institute for Integrative Cancer Research

30/01/2024 12:00 pm - 30/01/2024 1:00 pm
Location
Davis Auditorium

WEHI Special Inflammation Seminar hosted by Professor James Murphy
 

Professor Forest White
Koch Institute for Integrative Cancer Research at MIT; Faculty, MIT Center for Precision Cancer Medicine; Massachusetts Institute of Technology School of Engineering
 

Functional Proteomics for Clinical Insight

 

Davis Auditorium

Join via TEAMS

Including Q&A session

 

The focus of research in the White lab is the quantitative analysis of protein phosphorylation events regulating signal transduction cascades associated with cancer and other biological processes. Using mass spectrometry-based phosphoproteomics with a focus on tyrosine phosphorylation, our goal is to define the signaling networks that underlie cancer progression, metastasis, and therapeutic resistance. Coupling this approach to computational modeling enables the prediction of critical central nodes that represent putative therapeutic targets. We have applied this combination experimental-computational platform to identify therapeutic targets in a variety of cancer model systems ranged from genetically engineering mouse models to patient derived xenografts, and have validated targets experimentally using mono- and combination therapies. Recently these efforts have extended into analysis of hundreds of patient tumor tissue specimens using either frozen or FFPE-preserved sections. Our results from these analyses highlight the patient stratification and therapeutic diagnosis potential of our functional proteomics platform.

All welcome!

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