Cristina Lo Celso pioneered intravital microscopy of the haematopoietic stem cell (HSC) niche during her postdoctoral training at Harvard University. In 2009 she started her independent research group at Imperial College London, where she is now Professor of Stem Cell Biology in the department of Life Sciences, and co-director of the Centre for Haematology in the department of Immunology and Inflammation. Prof. Lo Celso also established a satellite laboratory at the Sir Francis Crick Institute. Her research aims to understand the mechanisms regulating HSC function during steady state and during stresses such as infections, leukaemia and transplantation. Her interdisciplinary approach combines mouse bone marrow intravital microscopy techniques, computational image analysis, molecular profiling and mathematical modelling of the HSC niche. Prof. Lo Celso’s publications have been cited over 7,000 times. She is the first woman to have received the Foulkes Medal award (2017) and this year she is receiving the first Maria Goeppert Mayer Medal for intravital microscopy research. She regularly engages in outreach activities and is keen to interact with the public, patients and industry.