Prof Anton Gartner – Ulsan National Institute of Science and Technology

27/10/2023 1:00 pm - 27/10/2023 2:00 pm
Davis Auditorium

WEHI Special BCBC Seminar hosted by Professor Andreas Strasser

Professor Anton Gartner

Associate Director, IBS Center for Genomic Integrity,
Distinguished Professor, Ulsan National Institute of Science and Technology, Republic of Korea


Experimental analysis of mutational signatures, correlation with cell death, implications for aging and cancer therapy


Davis Auditorium

Join via TEAMS

Including Q&A session

Download flyer



Cells possess an armamentarium of DNA repair pathways to counter DNA damage and prevent mutagenesis. Over the past 10 years, initially collaborating with the Sanger Center, we have used C. elegans, scanning through >3000 genomes to systematically investigate how mutagenesis is defined by the interplay of primary DNA damage and multiple repair processes (10.1038/s41467-020-15912-7; DOI: 10.1101/gr.226845.117, doi: 10.1101/gr.175547.114).


I will focus on our recent unpublished data using a large isogenic set of human DNA repair and damage response defective cell lines and our analysis of 500 genomes. Our results explain one of the mutational signatures associated with aging. Furthermore, I will discuss the multilayered response of cells to the methylating chemotherapeutic agent temozolomide (TMZ), which is used for treating glioblastomas. Our results allow us to correlate cell death, DNA repair status, and mutagenic signatures.

All welcome!

Support us

Together we can create a brighter future

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Sign up to our quarterly newsletter Illuminate

Find out about recent discoveries, community supporters and more.

Illuminate Summer 2023
View the current issue