The aim of our research group "Molecular Oncology" is to elucidate the basic principles restricting cell death in cancer and their relevance for clinical translation. We study the regulation of cell death in healthy and malignant cells. The focus of our work is the understanding of cell death mechanisms and their regulation in tumor cell initiation, tumor maintenance and resistance mechanisms. As model systems we employ genetic deletion or pharmacologic inhibition of individual cell death regulating proteins in various murine tumor models. In addition, we also employ spatiotemporal deletion of individual cell death regulating proteins for characterization of their role in tumor initiation and maintenance. Moreover, we place a specific focus on the rapid translation of murine data into patients. To accomplish this goal, we utilize a broad array of techniques from molecular biology, cell biology, mouse genetics and biochemistry in combination with a strong medical background. Our research covers a broad field of oncological disciplines, ranging from various hematological diseases over to different kinds of lung cancer. Due to the close interaction between scientists and clinicians we can realize translational cancer research in our daily work.
Philipp J. Jost (PJ) is full Professor of Clinical Oncology and Chair of the Clinical Department of Oncology and the University Palliative Care Unit at the Medical University of Graz, Austria. He is a board-certified hematologist and medical oncologist having received training at the Technical University of Munich, the Imperial College London as well as the Walter and Eliza Hall Institute in Melbourne. As a physician scientist, his lab focuses on the basic principles of oncogenic signaling, cell death and inflammation with a clear emphasis on the clinical context.