John McCauley – MSD, West Point, PA, USA

23/02/2024 11:00 am - 23/02/2024 12:00 pm
Davis Auditorium

WEHI Special Structural Biology seminar hosted by Professor Peter Czabotar

John McCauley
Senior Director, Department of Medicinal Chemistry, MSD, West Point, PA, USA

Protease Inhibitor Drug Discovery: Towards treatments for Covid-19 and Malaria


Davis Auditorium

Join via TEAMS

Including Q&A session


Inhibition of essential proteases is a successful drug invention strategy that has resulted in approved therapies across multiple diseases. The lecture will highlight some of MSD’s early work on HCV and HIV and will describe structure-based drug design strategies that have yielded a vast array of structurally diverse serine and aspartic acid protease inhibitors. This collection of compounds has provided a foundation for new infectious disease programs, including efforts towards inhibitors of Coronavirus 3CL Protease for the treatment of COVID-19 and inhibitors of Plasmepsin IX/X for the treatment of malaria, which will also be described.


John A. McCauley joined MSD, West Point, Pa., in 1998 and is currently a Senior Director in the Department of Medicinal Chemistry. Over the past 25 years, John and his group have been involved in the design and synthesis of fifteen compounds that have entered clinical development, including the combination therapy ZEPATIER (elbasvir/grazoprevir) for the treatment of hepatitis C virus infection and MK-7602, a Plasmepsin IX/X dual inhibitor for potential treatment of malaria. John currently has responsibility for Infectious Disease and Neglected Tropical Disease programs. He received a Ph.D. in organic chemistry from the University of Pennsylvania in the research group of Professor Amos B. Smith and worked with Professor Yoshito Kishi at Harvard University as an NIH postdoctoral fellow before beginning his career at MSD.


All welcome!

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