Aging dramatically affects the incidence of late-onset diseases, prompting questions about the potential link between cellular age and neurodegeneration. This presentation will detail the whole genome CRISPR/Cas9 and large scale in silico drug screening approaches we took to develop methods for measuring and manipulating cellular age in pluripotent stem cell derived neurons. It will also illustrate how these novel aging-inducing strategies, with a particular focus on the Neddylation pathway, can be used to accelerate the emergence of late-onset phenotypes in human pluripotent stem cell models of Alzheimer’s and Parkinson’s diseases.
Dr Nathalie Saurat is a Senior Research Scientist working with Dr Lorenz Studer at Memorial Sloan Kettering Cancer Center in New York. She earned her PhD in Dr Rick Livesey’s lab at the University of Cambridge. Dr Saurat is recognized for her expertise in the study of neurodegenerative diseases using human pluripotent stem cells. Her research primarily centers on the examination of cellular aging in the brain, encompassing approaches for its measurement and manipulation, as well as the intricate relationship between cellular aging and neurodegeneration.