Dr Nathalie Saurat – Memorial Sloan Kettering Cancer Center

23/11/2023 2:00 pm - 23/11/2023 3:00 pm
Davis Auditorium

WEHI Special Ubiquitin Signalling Seminar hosted by Professor David Komander

Dr Nathalie Saurat
Senior Research Scientist, Memorial Sloan Kettering Cancer Center, USA


Measuring and manipulating age in human stem cell models of neurodegenerative disease


Davis Auditorium

Join via TEAMS

Including Q&A session


Aging dramatically affects the incidence of late-onset diseases, prompting questions about the potential link between cellular age and neurodegeneration. This presentation will detail the whole genome CRISPR/Cas9 and large scale in silico drug screening approaches we took to develop methods for measuring and manipulating cellular age in pluripotent stem cell derived neurons. It will also illustrate how these novel aging-inducing strategies, with a particular focus on the Neddylation pathway, can be used to accelerate the emergence of late-onset phenotypes in human pluripotent stem cell models of Alzheimer’s and Parkinson’s diseases. 


Dr Nathalie Saurat is a Senior Research Scientist working with Dr Lorenz Studer at Memorial Sloan Kettering Cancer Center in New York. She earned her PhD in Dr Rick Livesey’s lab at the University of Cambridge. Dr Saurat is recognized for her expertise in the study of neurodegenerative diseases using human pluripotent stem cells. Her research primarily centers on the examination of cellular aging in the brain, encompassing approaches for its measurement and manipulation, as well as the intricate relationship between cellular aging and neurodegeneration. 


All welcome!

Support us

Together we can create a brighter future

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Sign up to our quarterly newsletter Illuminate

Find out about recent discoveries, community supporters and more.

Illuminate Spring 2023
View the current issue