Dr Madeline Dans – ACRF Chemical Biology division

04/10/2023 1:00 pm - 04/10/2023 2:00 pm
Davis Auditorium

WEHI Wednesday Seminar hosted by Dr Brad Sleebs

Dr Madeline Dans
Research Officer – Sleebs Laboratory, ACRF Chemical Biology division – New Medicines & Advanced Technologies Theme, WEHI

Stopping malaria parasites before they StART: uncovering the mechanism of action of novel antimalarials


Davis Auditorium

Join via SLIDO enter code #WEHIWednesday

Including Q&A session


Dr Madeline Dans completed her PhD at the Burnet Institute in 2021 with Associate Professor Paul Gilson, Professor Brendan Crabb and Associate Professor Tania de Koning-Ward (Deakin University) where she worked on identifying and characterising inhibitors of red blood cell egress and invasion of the malaria parasite P. falciparum.  


After her PhD, Madeline moved to WEHI to start her first postdoc in the groups of Dr Brad Sleebs and Professor Alan Cowman where she continues to work on elucidating targets and mechanism of action of novel antimalarial compounds. Madeline has a keen interest in screening assays, phenotypic drug assays and target deconvolution of novel compounds through various approaches including genomics and proteomics.  


This seminar will focus on a chemical series that she identified as a potential inhibitor of parasite red blood cell invasion in her PhD and has continued to work on in a collaboration between WEHI and the Burnet Institute. This study showcases the wide array of techniques and expertise at WEHI including medicinal chemistry, lattice light sheet imaging, parasite biology, high throughput drug screening, proteomics and biochemistry. 


All welcome!

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