Dr Si Ming Man - ANU College of Health and Medicine

Dr Si Ming Man - ANU College of Health and Medicine

Location: 
Davis Auditorium
Start Time: 
Mon, 17/06/2019 - 12:00pm
End Time: 
Mon, 17/06/2019 - 1:00pm

The Inflammasome: an anti-microbial machinery against bacterial infection

​Postgraduate lecture series hosted by Dr Greg Ebert

Recognition of pathogens by the host cell is of paramount importance for the initiation of an immune response and clearance of the pathogen. Intracellular and cytosolic bacteria infect host cells and replicate within a pathogen-containing vacuole or in the host cytoplasm. Sensing of the pathogen is mediated by extracellular and intracellular pattern-recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), AIM2-like receptors (ALRs) and RIG-I-like receptors (RLRs). Certain NLRs and ALRs induce the formation of an inflammasome, a cytoplasmic multi-protein complex which drives cell death and the release of the pro-inflammatory cytokines IL-1beta and IL-18. In this lecture, we will explore the concepts of innate immune recognition by inflammasome sensors and discuss how these fundamental innate immune pathways contribute to the host defense against bacterial infection.

Si Ming received his PhD from the University of Cambridge, United Kingdom, for his work on inflammasomes in the host defense against Salmonella infection. He obtained his postdoctoral training from St. Jude Children’s Research Hospital, USA, where he studied inflammasome signalling in the host response to infection and cancer. Currently, he is a Group Leader and NHMRC R.D. Wright Biomedical Fellow at the Australian National University, where his laboratory focuses on innate immunity in the host defense against infectious diseases and the development of cancer.