Dr Michael Milevskiy - ACRF Cancer Biology & Stem Cells division

Dr Michael Milevskiy - ACRF Cancer Biology & Stem Cells division

Location: 
Davis Auditorium
Start Time: 
Wed, 05/10/2022 - 1:00pm
End Time: 
Wed, 05/10/2022 - 2:00pm

WEHI Wednesday Seminar hosted by Professor Jane Visvader

Dr Michael Milevskiy

Senior Research Officer - Breast Cancer Laboratory


ACRF Cancer Biology & Stem Cells division – Cancer Research & Treatments Theme, WEHI



Transcriptional Regulation of the Mammary Stem Cell Hierarchy




Davis Auditorium

Online access via Slido
and enter code WEHIWednesday


Including Q&A session



The mammary gland defines mammals within the animal kingdom, and its function is to provide nutrients to offspring in the early stages of life. Most development of this organ occurs during puberty to form a full ductal tree and again during pregnancy to initiate lactation. Breast ducts are composed of an epithelial bilayer and these cells are the source of breast tumours that arise in 1 in 8 women.

Transcriptional regulation is a complex and multifaceted biological process. Cis-regulatory elements (CREs) are response for complex fine-tuning of gene expression in a tissue-specific manner. CREs are essential for development as genetic manipulation can led to a failure in development and potentially tumourigenesis. Many questions remain as to how gene regulation defines each of the epithelial lineages and the nature of chromatin in mammary stem cells. We sought to comprehensively characterise the transcriptomic and epigenetic landscape of the different epithelial cells, uncovering key differences in lineage chromatin profiles.

 

All welcome!