Dr J Shaun Lott - University of Auckland

Dr J Shaun Lott - University of Auckland

Location: 
Davis Auditorium
Start Time: 
Wed, 22/03/2017 - 9:30am
End Time: 
Wed, 22/03/2017 - 10:30am

​The role of structural analysis in biological discovery: Illustration, Explanation or Illumination?

​Special seminar hosted by Professor Tony Burgess

The analysis of protein structure is now central to many aspects of the biological discovery process and its application to biomedical research. This seminar will address different ways in which the understanding of protein structure can inform biological investigation. For example, the determination of the first structure of an RHS-repeat-containing protein enabled the prediction of function for this previously mysterious protein family. In contrast, the determination of protein structures from the human pathogen Mycobacterium tuberculosis has enabled the rationalization of previous biochemical and genetic data, and may lead to the identification of antibacterial compounds with novel modes of action compared to current antibiotic therapies.

Shaun Lott is currently an Associate Professor in Structural Biology at the University of Auckland, New Zealand, and a Principal Investigator of the Maurice Wilkins Centre for Molecular Biodiscovery, a New Zealand Centre for Research Excellence. His laboratory has a long-standing in bacterial pathogenesis, with a focus on the human pathogen Mycobacterium tuberculosis. His undergraduate training and graduate training was in the UK: he studied biochemistry at the University of Surrey, and obtained his PhD in molecular biology from the University of Leeds.