Dr Danielle Sliter - National Institute of Health

Dr Danielle Sliter - National Institute of Health

Location: 
Davis Auditorium
Start Time: 
Tue, 20/11/2018 - 1:00pm
End Time: 
Tue, 20/11/2018 - 2:00pm

​Mitophagy and Inflammation: Connecting mitochondrial dysfunction and neurodegeneration

Special seminar hosted by Dr David Komander

The proteins Parkin and PINK1, commonly mutated in inherited forms of Parkinson's disease, function to clear damaged mitochondria from cells in a process termed mitophagy.  While mitochondrial dysfunction is known to induce inflammation and inflammation  and mitochondrial dysfunction are associated with Parkinson's disease, how these may contribute to disease is unknown.  Danielle’s work demonstrates that mitochondrial dysfunction and failed mitophagy together trigger a STING-driven inflammatory response.  This appears to contribute to neuron loss in a mouse model of Parkinson's disease, highlighting an unanticipated role for mitophagy in mitigating inflammation and a novel link to Parkinson's disease.

Danielle earned her undergraduate degree in Biology at Syracuse University, in Syracuse NY. Then pursued her doctoral studies at SUNY Upstate Medical University.  In the lab of Richard Wojcikiewicz, she used mass spectrometry to study the ubiquitination of IP3 receptors.  She then went on to post-doc with Dr Richard Youle at the National Institute of Neurological Disorders and Stroke at the NIH in Bethesda MD.  Her work focused on the role of ubiquitin-binding proteins in the clearance of damaged mitochondrial and on the consequences of failed mitochondrial clearance on inflammation.