Dr Cyril Seillet - Molecular Immunology division

Dr Cyril Seillet - Molecular Immunology division

Location: 
Davis Auditorium
Start Time: 
Wed, 21/06/2017 - 1:00pm
End Time: 
Wed, 21/06/2017 - 2:00pm

Understanding the physiological regulation of innate immunity

Wednesday seminar

The basis for personalized medicine is that unique aspects of our biology will define novel targets and strategies for more effective prevention and treatment of immune-related diseases. To develop such therapies, it is important to understand how our physiological parameters influence the immune responses. Despite the crucial role of the hormonal regulation and circadian rhythm on numerous biological processes, consideration for their influence on the immune system only starts to emerge. Supported by a Career Development Fellowship and a Project Grant New Investigator (NHMRC), Dr Seillet’s research aims to understand how these parameters regulate the innate immune cells and their consequences on the development of inflammatory diseases.

In 2011, Cyril obtained his PhD in France, during which he studied the role of estrogens and their nuclear receptors in the development and the effector functions of dendritic cells. He pursued his research in Professor Gabrielle Belz’s laboratory at the Walter and Eliza Hall Institute where he pioneered the transcriptional regulation of the innate lymphoid cells with the identification of key checkpoints required for their development.

During this seminar, Dr Seillet will discuss about the sex-differences observed in innate immunity that contribute to the marked differences seen in the susceptibility to autoimmune disease and allergic responses in males and females. He will also present pioneering work on the circadian regulation of the innate cells and how this process may help the immune system to anticipate pathogen threats during activity time while promoting repair and recovery during resting phase.