Dr Christine Biben, Epigenetics and Development division

Dr Christine Biben, Epigenetics and Development division

Start Time: 
Wed, 10/03/2021 - 1:00pm
End Time: 
Wed, 10/03/2021 - 2:00pm

WEHI Wednesday Seminar hosted by Dr Samir Taoudi

Dr Christine Biben
Senior Research Officer - Taoudi Lab, Epigenetics and Development division - Healthy Development and Ageing Theme

Using in vivo cellular barcoding to determine the origin of blood

Join via TEAMS
Includes Q&A session

During embryogenesis, haematopoietic and endothelial lineages emerge in close proximity to each other. This has led to the enduring hypothesis that haematopoietic and endothelial lineages share ancestry via common precursors (haemangioblast, haematogenic endothelium). Using single cell RNA-Sequencing and a novel in vivo cellular barcoding mouse line, the LoxCode mouse, we mapped the cellular ancestry that underlies the diversification of the extraembryonic mesoderm into its main derivatives: blood, endothelium and mesenchyme. We found that in the yolk sac, haematopoietic, endothelial, and mesenchymal trajectories are seeded by three bipotential precursors (haemangioblasts (blood and endothelium), angiomesoblasts (endothelium and mesenchyme) and haematomesoblast (blood and mesenchyme)). Therefore, while blood and endothelium can share ancestry, this association is not exclusive.