Douglas M. Fowler - University of Washington School of Medicine

Douglas M. Fowler - University of Washington School of Medicine

Location: 
Online via TEAMS
Start Time: 
Wed, 04/08/2021 - 9:30am
End Time: 
Wed, 04/08/2021 - 10:30am

WEHI Special NMAT Lecture hosted by Dr Rory Bowden – Advanced Technology & Biology division

 

Douglas M. Fowler, PhD

Associate Professor, Department of Genome Sciences, University of Washington School of Medicine

 

Developing an atlas of genetic variant effects 

 

Join via TEAMS

Including Q&A session

 

How does a protein’s sequence encode its fold and function?  How do changes in sequence influence disease risk, prognosis and treatment? How do gene expression patterns combine with protein activity to define cellular processes like growth, migration and communication? My lab is interested in finding new ways to probe the relationship between genotype and phenotype, enabling us to better answer these questions. In particular, we have developed new, scalable methods to measure the effect of variants on molecular and cellular phenotypes. We have also applied these methods to better understand the meaning of variants in human genomes, reveal a new insights into protein structure, and enable prediction of variant impact.

 

Dr Fowler earned a PhD in chemistry at The Scripps Research Institute where, working with Dr Jefferey Kelly and Dr William Balch, he discovered and characterized the first mammalian functional amyloid protein.  Following a postdoctoral fellowship with Dr Stanley Fields, he began his independent career at the University of Washington. He has focused on developing and implementing new technologies to address difficult problems in genomics. Dr Fowler is a leader in high-throughput, sequencing-based assays, and his lab has deep expertise in large-scale experimental approaches and computational analyses. He is now working to understand the effects of the millions of variants found in a typical human genome. Dr Fowler is an Associate Professor of Genome Sciences and an Adjunct Associate Professor of Bioengineering at the University of Washington.  He is Director of the Center for the Multiplexed Assessment of Phenotype, an NHGRI Center of Excellence; co-founder of the Atlas of Variant Effects Alliance; and a CIFAR Azrieli Global Scholar.

 

All welcome!