Dimitri Krainc - Feinberg School of Medicine, USA

Dimitri Krainc - Feinberg School of Medicine, USA

Location: 
Online
Start Time: 
Fri, 07/05/2021 - 9:30am
End Time: 
Fri, 07/05/2021 - 10:30am

WEHI Parkinson’s Disease Special Seminar hosted by Associate Professor Grant Dewson

 

Dimitri Krainc, MD, PhD

Aaron Montgomery Ward Professor, Chairman - Department of Neurology, Director - Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, USA


 

The Interplay of Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease

 

Join via ZOOM

Webinar ID: 863 5312 7158

Passcode: 853287

Including Q&A session





Dimitri Krainc, MD, PhD currently serves as the Aaron Montgomery Ward Professor and Chairman of the Department of Neurology and Director of the Center for Neurogenetics at Northwestern University, Feinberg School of Medicine in Chicago.   Previously, Dr. Krainc spent more than 20 years at Harvard Medical School where he completed his research training (PhD and postdoc) followed by a neurology residency and fellowship in movement disorders at Massachusetts General Hospital. He then served on the neurology faculty at MGH and Harvard Medical School until 2013 when he relocated to Chicago. The overarching goal of his laboratory has been to define molecular pathways in the pathogenesis of neurodegeneration and identify specific therapeutic targets. His work provided the mechanistic link between Parkinson’s disease and Gaucher’s disease caused by mutations in the glucocerebrosidase gene and first demonstrated decreased glucocerebrosidase activity in idiopathic PD (Cell, 2011). His work in iPS-derived neurons PD identified a pathological cascade of mitochondrial and lysosomal dysfunction in genetic and sporadic forms of PD that was mediated by dopamine oxidation in human, but not mouse dopaminergic neurons (Science, 2017). These findings highlighted the importance of studying PD mechanisms in patient-derived neurons and at least in part explained why animal models of genetic forms of PD do not recapitulate human disease. Based on detailed mechanistic understanding in PD patient neurons, his lab has developed targeted therapeutic approaches that partially ameliorate pathogenic phenotypes (Science Translational Medicine, 2019)

 

His group has also identified the formation of direct mitochondria-lysosome membrane contacts that mark sites for lysosomal regulation of mitochondrial networks, and vice versa, providing a new angle to studies these organelles in neurodegenerative diseases including PD (Wong et al, Nature, 2018).

 

All welcome!

 

Full ZOOM link: https://us02web.zoom.us/j/86353127158?pwd=UzIxVGIwVVlkSDdCNFEvaXd2eC80UT09