Associate Professor Seth Masters - Inflammation division

Associate Professor Seth Masters - Inflammation division

Davis Auditorium
Start Time: 
Wed, 14/07/2021 - 1:00pm
End Time: 
Wed, 14/07/2021 - 2:00pm

WEHI Wednesday Seminar hosted by Associate Professor James Murphy


Associate Professor Seth Masters

Laboratory Head, Inflammation division - Infection, Inflammation & Immunity Theme


New autoinflammatory diseases reveal innate immune pathways underlying diverse pathology



Davis Auditorium

Online access via Slido and enter code #WEHIWEDNESDAY

Including Q&A session


The Masters laboratory manage the Australian Autoinflammatory Disease Registry (AADRY), identifying genetic mutations which cause these conditions. This provides insight into fundamental innate immune pathways from which surprising links can be made. For example, they recently identified novel mutations in Sting Associated Vasculopathy with onset in Infancy, and then also found that Sting can also be triggered in the neurological condition motor neuron disease (also known as ALS).


In this talk, unpublished data will be presented that identifies DPP9 deficiency, an autoinflammatory disease due to increased NLRP1 inflammasome activation. Genetic variants in NLRP1 help to explain how this immune sensor is linked to conditions such as inflammatory bowel disease and asthma, indicating where pharmacological intervention may be possible.



All welcome!