Associate Professor Isabelle Lucet- ACRF Chemical Biology division

Associate Professor Isabelle Lucet- ACRF Chemical Biology division

Location: 
Davis Auditorium
Start Time: 
Wed, 13/11/2019 - 1:00pm
End Time: 
Wed, 13/11/2019 - 2:00pm
 

The power of non-catalytic functions: redefining kinase signalling pathways

 

Wednesday seminar​ hosted by Professor Guillaume Lessene

Aberrant signalling by the protein kinase family is a known driving force for many cancers and inflammatory diseases. Over the past two decades, considerable investments have been made to specifically and selectively block the catalytic activity of oncogenic kinases. However, despite the evident progress, many ATP kinases competitive inhibitors currently in the clinic still lack selectivity, leading to significant side effects. One critical understudied feature of kinases is their ability to integrate numerous essential cellular functions and effectively tune the amplitude of biological outputs through catalytic-independent signaling mechanisms. These catalytic-independent functions became evident with the study of Pseudokinases, a catalytically dead subset of kinase-like proteins known to contribute to many human diseases, including cancers, when mutated or overexpressed. Capitalising on years of expertise in the field, the Lucet lab focuses on elucidating how the non-catalytic functions of the kinase scaffold dynamically assemble and regulate the multiprotein molecular assembly of oncogenic signalling networks.  Our group aims to establish an integrated framework to develop novel therapeutic strategies to counteract kinase driven diseases.

Associate Professor Isabelle Lucet obtained her PhD at the University of Angers (France) in Biochemistry and Biophysics. She then undertook her postdoctoral studies in Oxford (UK) where she developed her interest in kinase signal transduction pathways. In 2001, she relocated to Australia to develop research programs at the interface between academia and industry. Since, she has made seminal contributions in the field of protein kinase research and transferred this knowledge into therapies in the cancer and immunology areas.  She is currently heading the ACRF Chemical Biology division at the Walter and Eliza Hall Institute of Medical Research.