Associate Professor Diana Hansen - Infectious Diseases & Immune Defence division

Associate Professor Diana Hansen - Infectious Diseases & Immune Defence division

Online via TEAMS
Start Time: 
Wed, 04/08/2021 - 1:00pm
End Time: 
Wed, 04/08/2021 - 2:00pm

WEHI Wednesday Seminar hosted by Professor Marc Pellegrini


Associate Professor Diana Hansen

Laboratory Head, Infectious Diseases & Immune Defence division - Infection, Inflammation & Immunity Theme

Systems immunology approaches to understanding immunity to infectious diseases: the end of the double-edged sword


Join via TEAMS

Including Q&A session


A/Prof Diana Hansen is a Laboratory Head in the Division of Infectious Disease and Immune Defence. Her research focuses on finding solutions to tackle two devastating mosquito-borne infectious diseases, malaria and dengue, which together account for 600 million clinical cases worldwide annually. In 2020, Diana also turned into COVID-19 research, setting up clinical studies in Australia and overseas. Her main interests include understanding mechanisms regulating pathogenesis and immunity to these infectious diseases.


Individuals living in malaria endemic areas develop clinical immunity only after many years of repeated infections. Clinical immunity is not sterilising but prevents symptomatic episodes by substantially reducing parasite burden, with adults often experiencing asymptomatic malaria. Using pre-clinical infection models and systems immunology approaches to human studies in malaria endemic areas, the Hansen Lab is addressing three key questions in the field: 1) what is the mechanism underlying the slow and imperfect acquisition of immunity to malaria; 2) what are the immunological signatures associated with protection from infection and 3) what is the real impact that persistent asymptomatic malaria infections have on the host.


Undertanding these questions is critical to inform the design of malaria vaccines and to provide a framwork for the implementation of screening and treatment of asymptomatic malaria, which would immediatley reduce ongoing transmission and benefit current eradication efforts.



All welcome!